Homburg Cream & Sugar Study (HCS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00628524
Recruitment Status : Completed
First Posted : March 5, 2008
Last Update Posted : December 9, 2013
Information provided by (Responsible Party):
Ulrich Laufs, University Hospital, Saarland

Brief Summary:
The purpose of this study is to prospectivly analyze the correlation of triglyceride tolerance and glucose tolerance with cardiovascular morbidity and mortality in patients with stable coronary artery disease within 18 months and to determine, whether measurement of triglyceride tolerance can discriminate patients at risk for cardiovascular events.

Condition or disease
Coronary Artery Disease Diabetes Metabolic Syndrome Glucose Tolerance Hyperlipidemia

Study Type : Observational
Actual Enrollment : 514 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Prospective Investigation of the Influence of Triglyceride Tolerance on Cardiovascular Outcomes in Patients With Coronary Artery Disease
Study Start Date : February 2008
Actual Primary Completion Date : July 2013
Actual Study Completion Date : August 2013

Resource links provided by the National Library of Medicine

> 500 consecutive patients with coronary artery disease fulfilling eligibility criteria.

Primary Outcome Measures :
  1. Parameters of triglyceride tolerance and glucose tolerance in correlation to cardiovascular events, cardiovascular mortality, total mortality. [ Time Frame: 48 months after inclusion. ]

Secondary Outcome Measures :
  1. Waist-to-Hip ratio, nutrition protocol, physical activity, non-invasive endothelial function, body fat composition, other biomarkers of lipid and glucose metabolism. [ Time Frame: Directly after inclusion. ]

Biospecimen Retention:   Samples Without DNA

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
> 500 consecutive patients with stable coronary artery disease being treated in the cardiology department of the university hospital.

Inclusion Criteria:

  • Stable CAD

Exclusion Criteria:

  • Acute Coronary Syndrom
  • Relevant Arrhythmias
  • Severe valvular heart disease
  • Decompensated heart failure
  • Severe inflammtory disease (infectious, rheumatoid)
  • Metabolic diseases (e.g. thyroid)
  • Inability to swallow
  • Liver or kidney failure
  • Lactose intolerance
  • Fat intolerance (e.g. chronic pancreatitis, gall stones)
  • Malignant Disease
  • Psychiatric Diseases (including alcohol / drug abuse)
  • Pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00628524

University Hospital Homburg / Saar - Cardiology Department
Homburg, Saarland, Germany, 66421
Sponsors and Collaborators
University Hospital, Saarland
Principal Investigator: Ulrich Laufs, MD University Hospital, Saarland

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Ulrich Laufs, Prof. Dr. Ulrich Laufs, University Hospital, Saarland Identifier: NCT00628524     History of Changes
Other Study ID Numbers: HCS Study
First Posted: March 5, 2008    Key Record Dates
Last Update Posted: December 9, 2013
Last Verified: December 2013

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Metabolic Syndrome X
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases
Lipid Metabolism Disorders