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Vitamin A, Its Receptors and Asthma

This study has been withdrawn prior to enrollment.
Information provided by (Responsible Party):
Selina Gierer, D.O., University of Kansas Identifier:
First received: February 26, 2008
Last updated: May 3, 2012
Last verified: May 2012
We wish to understand the association of Vitamin A serum levels and Vitamin A receptor number and responsiveness in asthmatics. We believe that Vitamin A receptors may be less prevalent in asthmatics and their responsiveness decreased.


Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Vitamin A, Its Receptors and Asthma: Vitamin A Levels in Serum and Expression and Responsiveness of Vitamin A Receptors in Circulating Mononuclear Cells of Asthmatics

Resource links provided by NLM:

Further study details as provided by Selina Gierer, D.O., University of Kansas:

Primary Outcome Measures:
  • Retinol levels in blood, flow cytometric study of the RXRRAR receptors before and after addition of ATRA, 9-cis-RA and steroid [ Time Frame: 2-4 weeks after blood sample drawn ]

Biospecimen Retention:   Samples With DNA
Serum without DNA, cells with DNA

Enrollment: 0
Study Start Date: May 2008
Estimated Study Completion Date: December 2012
Estimated Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)

Detailed Description:
We wish to define the association of asthma, vitamin A serum levels and vitamin A receptor number and responsiveness on circulating mononuclear cells. Asthma is a complex, heterogenous and often debilitating and potentially deadly disease. The causes for asthma are many, with susceptibility and resistance to treatment is poorly understood. Ultimately, looking at this disease from another angle such as the role of Vitamin A and/or receptors can help us learn more about the pathophysiology and treatment of asthma.

Ages Eligible for Study:   18 Years to 64 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Male or female Age 18-64

Inclusion Criteria:

  • Patients with previously diagnosed asthma on inhaled corticosteroids, systemic steroids and/or long acting beta agonist (for a period of 6 mo to 5 years)
  • Age 18-64
  • Male or female

Exclusion Criteria:

  • Children under age 18
  • Adults 65 or older
  • Patients with COPD
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Please refer to this study by its identifier: NCT00628329

United States, Kansas
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Sponsors and Collaborators
University of Kansas
Principal Investigator: Daniel Stechschulte, MD University of Kansas Medical Center
  More Information

Responsible Party: Selina Gierer, D.O., Assistant Professor, University of Kansas Identifier: NCT00628329     History of Changes
Other Study ID Numbers: 11213
Study First Received: February 26, 2008
Last Updated: May 3, 2012

Keywords provided by Selina Gierer, D.O., University of Kansas:
asthma, retinol, cis-retinoic acid

Additional relevant MeSH terms:
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases
Vitamin A
Retinol palmitate
Growth Substances
Physiological Effects of Drugs
Molecular Mechanisms of Pharmacological Action
Protective Agents
Anticarcinogenic Agents
Antineoplastic Agents processed this record on August 18, 2017