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Energetic Abnormalities in Heart Failure With Preserved Ejection Fraction

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2008 by University Hospital Birmingham.
Recruitment status was:  Recruiting
Heart of England NHS Trust
British Heart Foundation
Information provided by:
University Hospital Birmingham Identifier:
First received: February 24, 2008
Last updated: NA
Last verified: February 2008
History: No changes posted
Up to half of all patients with heart failure are found to have normal pumping function of the heart muscle, but show abnormalities in the way the heart muscle relaxes and fills with blood. These patients often have high blood pressure, and tend to have stiff arteries and stiff heart muscle. We wish to test the hypothesis that these patients have abnormal energy stores in their heart muscle.

Heart Failure, Diastolic

Study Type: Observational
Study Design: Observational Model: Cohort
Official Title: Energetic Abnormalities in Heart Failure With Preserved Ejection Fraction

Resource links provided by NLM:

Further study details as provided by University Hospital Birmingham:

Primary Outcome Measures:
  • Complete echocardiographic assessment to assess resting diastolic function [ Time Frame: 1 DAY ]
  • Assessment of resting large artery function [ Time Frame: 1 DAY ]
  • Multiple Gated Acquisition Scan [ Time Frame: 1 DAY ]
  • Cardiac Magnetic Resonance Spectroscopy [ Time Frame: 1 DAY ]
  • Metabolic Exercise Testing (VO2max) [ Time Frame: 1 DAY ]

Estimated Enrollment: 50
Study Start Date: March 2006
Estimated Study Completion Date: April 2009
Estimated Primary Completion Date: April 2009 (Final data collection date for primary outcome measure)
Patients with Heart Failure with preserved ejection fraction
Healthy Volunteers


Ages Eligible for Study:   40 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Heart Failure Clinic

Inclusion Criteria:

  • Clinical features consistent with heart failure
  • LVEF ≥ 50%, with no evidence of significant valvular disease, no hypertrophic cardiomyopathy, and no evidence of pericardial constriction
  • A peak VO2 < 80% predicted, with a pattern of gas exchange on metabolic exercise testing indicating a cardiac cause for limitation

Exclusion Criteria:

  • Objective evidence of lung disease on formal lung function testing
  • Reversible myocardial ischaemia on contrast-enhanced myocardial stress
  • Echocardiography, and evidence of exercise-induced mitral regurgitation
  • Obesity (BMI >35) or a locomotor cause for exercise limitation
  Contacts and Locations
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Please refer to this study by its identifier: NCT00628082

Contact: Thanh T Phan, MRCP 01214145916

United Kingdom
University of Birmingham Recruiting
Birmingham, United Kingdom, B15 2TT
Contact: Thanh T Phan, MRCP    01214145916   
Sub-Investigator: Thanh T Phan, MRCP         
Sponsors and Collaborators
University Hospital Birmingham
Heart of England NHS Trust
British Heart Foundation
Principal Investigator: Michael Frenneaux, FRCP University of Birmingham
  More Information

Responsible Party: Prof Michael Frenneaux, University of Birmingham Identifier: NCT00628082     History of Changes
Other Study ID Numbers: RRK 2996
Study First Received: February 24, 2008
Last Updated: February 24, 2008

Keywords provided by University Hospital Birmingham:
Cardiac Energetics
Dynamic Diastolic filling Assessment
Heart Failure with Preserved Ejection Fraction
Arterial and Ventricular Stiffening

Additional relevant MeSH terms:
Heart Failure
Heart Failure, Diastolic
Heart Diseases
Cardiovascular Diseases processed this record on July 19, 2017