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Efficacy of Keppra in Acute Alcohol Related Seizure Control--A Pilot Study

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2008 by Medical University of South Carolina.
Recruitment status was:  Not yet recruiting
UCB Pharma
Information provided by:
Medical University of South Carolina Identifier:
First received: February 20, 2008
Last updated: October 23, 2008
Last verified: February 2008
Pilot study to evaluate efficacy of Keppra (levetiracetam) for seizure control in patients with alcohol related seizures.

Condition Intervention Phase
Seizure, Alcohol Related
Drug: levetiracetam
Phase 2

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Pilot Study Examining the Efficacy of Keppra in Acute Alcohol Related Seizure Control in the Emergency Department Setting

Resource links provided by NLM:

Further study details as provided by Medical University of South Carolina:

Primary Outcome Measures:
  • Decreased seizures [ Time Frame: 1, 2, 4, 8 weeks ]

Estimated Enrollment: 20
Study Start Date: February 2008
Estimated Primary Completion Date: July 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1 Drug: levetiracetam
2 gram iv load, 500mg bid


Ages Eligible for Study:   18 Years to 64 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • No trauma
  • Not pregnant
  • No other cause for seizure (hypoglycemia, CNS causes, trauma)
  • Good family support
  • Working telephone contact

Exclusion Criteria:

  • Pregnancy
  • Renal failure (creatine > 2mg/dl
  • Fever or illness
  • Hypotension
  • Any trauma
  Contacts and Locations
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Please refer to this study by its identifier: NCT00627133

Contact: Amy Robins, MD 843-792-9709
Contact: Keith Borg, MD PhD 843-792-9709

United States, South Carolina
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Sponsors and Collaborators
Medical University of South Carolina
UCB Pharma
  More Information

Responsible Party: Keith Borg MD PhD, Medical University of South Carolina Identifier: NCT00627133     History of Changes
Other Study ID Numbers: K17644
Study First Received: February 20, 2008
Last Updated: October 23, 2008

Keywords provided by Medical University of South Carolina:
Alcohol seizure

Additional relevant MeSH terms:
Alcohol Withdrawal Seizures
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Alcohol-Induced Disorders, Nervous System
Neurotoxicity Syndromes
Chemically-Induced Disorders
Alcohol-Induced Disorders
Alcohol-Related Disorders
Substance-Related Disorders
Substance Withdrawal Syndrome
Anti-Infective Agents, Local
Anti-Infective Agents
Central Nervous System Depressants
Physiological Effects of Drugs
Nootropic Agents processed this record on May 23, 2017