We updated the design of this site on December 18, 2017. Learn more.
ClinicalTrials.gov Menu

Efficacy of Keppra in Acute Alcohol Related Seizure Control--A Pilot Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00627133
Recruitment Status : Unknown
Verified February 2008 by Medical University of South Carolina.
Recruitment status was:  Not yet recruiting
First Posted : February 29, 2008
Last Update Posted : October 24, 2008
Information provided by:

Study Description
Brief Summary:
Pilot study to evaluate efficacy of Keppra (levetiracetam) for seizure control in patients with alcohol related seizures.

Condition or disease Intervention/treatment Phase
Seizure, Alcohol Related Drug: levetiracetam Phase 2

Study Design

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 20 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Pilot Study Examining the Efficacy of Keppra in Acute Alcohol Related Seizure Control in the Emergency Department Setting
Study Start Date : February 2008
Estimated Primary Completion Date : July 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Seizures
U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Experimental: 1 Drug: levetiracetam
2 gram iv load, 500mg bid

Outcome Measures

Primary Outcome Measures :
  1. Decreased seizures [ Time Frame: 1, 2, 4, 8 weeks ]

Eligibility Criteria

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years to 64 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • No trauma
  • Not pregnant
  • No other cause for seizure (hypoglycemia, CNS causes, trauma)
  • Good family support
  • Working telephone contact

Exclusion Criteria:

  • Pregnancy
  • Renal failure (creatine > 2mg/dl
  • Fever or illness
  • Hypotension
  • Any trauma
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00627133

Contact: Amy Robins, MD 843-792-9709 robins@musc.edu
Contact: Keith Borg, MD PhD 843-792-9709 borgk@musc.edu

United States, South Carolina
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Sponsors and Collaborators
Medical University of South Carolina
UCB Pharma
More Information

Responsible Party: Keith Borg MD PhD, Medical University of South Carolina
ClinicalTrials.gov Identifier: NCT00627133     History of Changes
Other Study ID Numbers: K17644
First Posted: February 29, 2008    Key Record Dates
Last Update Posted: October 24, 2008
Last Verified: February 2008

Keywords provided by Medical University of South Carolina:
Alcohol seizure

Additional relevant MeSH terms:
Alcohol Withdrawal Seizures
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Alcohol-Induced Disorders, Nervous System
Neurotoxicity Syndromes
Chemically-Induced Disorders
Alcohol-Induced Disorders
Alcohol-Related Disorders
Substance-Related Disorders
Substance Withdrawal Syndrome
Anti-Infective Agents, Local
Anti-Infective Agents
Central Nervous System Depressants
Physiological Effects of Drugs
Nootropic Agents