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Labor Analgesia With Ropivacaine and Clonidine (LA)

This study has been completed.
Faculdade de Medicina de Botucatu, UNESP, Botucatu, Brasil
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Information provided by (Responsible Party):
Yara Marcondes Machado Castiglia, UPECLIN HC FM Botucatu Unesp Identifier:
First received: February 20, 2008
Last updated: July 7, 2015
Last verified: February 2008
The aim of the present study was to examine, for pain relief during labor, the efficacy of two pharmacological approaches — the 0.125% ropivacaine alone and the 0.0625% ropivacaine added to 75 ug clonidine, both by epidural administration. The effect of the drugs on mother and newborn was also determined.

Condition Intervention
Labor Pain
Drug: ropivacaine
Drug: ropivacaine and clonidine

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Labor Analgesia With Ropivacaine Added to Clonidine. A Randomized Clinical Trial

Resource links provided by NLM:

Further study details as provided by UPECLIN HC FM Botucatu Unesp:

Enrollment: 32
Study Start Date: May 2000
Study Completion Date: December 2001
Primary Completion Date: May 2000 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
R group:15 mL of 0.125% ropivacaine (18.75 mg)
Drug: ropivacaine
15 ml of ropivacaine 0.125% peridural once
RC group:0.0625% ropivacaine (9.375 mg) plus 75 ug clonidine
Drug: ropivacaine and clonidine
15 ml of ropivacaine 0.0625% plus 75 mcg clonidine


Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Women having requested epidural analgesia for labor and hers newborns

Inclusion Criteria:

  • Singleton healthy
  • Full-term pregnancy
  • American Society of Anesthesiologists physical status I or II

Exclusion Criteria:

  • Patients who had received opioids
  • History of hypersensitivity to local anesthetic or to clonidine
  • Fetus showed signs of possible intrauterine suffering
  • Fetus showed signs of possible neurological deficit
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Please refer to this study by its identifier: NCT00626977

College of Medicine of Botucatu
Botucatu, São Paulo, Brazil, 18618970
Sponsors and Collaborators
UPECLIN HC FM Botucatu Unesp
Faculdade de Medicina de Botucatu, UNESP, Botucatu, Brasil
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Principal Investigator: Giane Nakamura, MD PHd College Study of Medicine
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Yara Marcondes Machado Castiglia, MD PhD, UPECLIN HC FM Botucatu Unesp Identifier: NCT00626977     History of Changes
Other Study ID Numbers: upeclin/HC/FMB-Unesp-07
Study First Received: February 20, 2008
Last Updated: July 7, 2015

Keywords provided by UPECLIN HC FM Botucatu Unesp:
Anesthetics, local
Pregnant women
Infant, newborn

Additional relevant MeSH terms:
Labor Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Anesthetics, Local
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Antihypertensive Agents
Autonomic Agents
Adrenergic alpha-2 Receptor Agonists
Adrenergic alpha-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action processed this record on April 28, 2017