The Effects of Walnuts on Antioxidant Capacity and Nutritional Status in Humans
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ClinicalTrials.gov Identifier: NCT00626691 |
Recruitment Status
:
Completed
First Posted
: February 29, 2008
Last Update Posted
: February 19, 2009
|
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Healthy | Behavioral: Walnut consumption | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 24 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Prevention |
Official Title: | The Effects of Walnuts on Antioxidant Capacity and Nutritional Status in Humans |
Study Start Date : | February 2007 |
Actual Primary Completion Date : | December 2007 |
Actual Study Completion Date : | December 2007 |

-
Behavioral: Walnut consumption
- Nutritional status and antioxidant capacity [ Time Frame: 5 months ]

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Ages Eligible for Study: | 50 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Generally healthy men and postmenopausal women age 50 or over
- BMI 18.5-35 kg/m2
Exclusion Criteria:
- Cigarette smoking and/or nicotine replacement use
- History or known allergy to nuts of any kind
- Regular consumption of ≥ 5 oz nuts/week for 6 weeks prior to study admission
- Individuals taking estrogen
- Use of cholesterol-lowering medications
- Gastrointestinal disease
- Kidney disease
- Endocrine disease: including diabetes, untreated thyroid disease
- Rheumatoid arthritis
- Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission
- Systolic blood pressure > 150 mmHg and/or diastolic blood pressure > 95 mmHg
- Regular use of oral steroids
- Regular daily intake of ≥ 2 alcoholic drinks
- Illicit drug use
- No fish oil supplements (including cod liver oil) for 6 weeks prior to study admission
- No high dose (≥ 3X RDA) supplements of vitamins C, E, selenium, or beta-carotene for one month prior to study admission
- No dietary supplements containing phenolic compounds, i.e., herbal preparations, or berry containing preparations (such as cranberry capsules) for one month prior to study admission
- No regular consumption of pomegranate juice (≥ 180 mL or 6 oz/d, ≥ 3 times/wk) for one month prior to study admission

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00626691
United States, Massachusetts | |
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University | |
Boston, Massachusetts, United States, 02111 |
Principal Investigator: | Diane L McKay, PhD | Tufts Medical Center |
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Diane McKay, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University |
ClinicalTrials.gov Identifier: | NCT00626691 History of Changes |
Other Study ID Numbers: |
PV2707 |
First Posted: | February 29, 2008 Key Record Dates |
Last Update Posted: | February 19, 2009 |
Last Verified: | February 2009 |
Keywords provided by Tufts University:
antioxidant walnut nutritional status Antioxidant capacity |
Additional relevant MeSH terms:
Antioxidants Molecular Mechanisms of Pharmacological Action Protective Agents Physiological Effects of Drugs |