Examining How Heart Disease Risk Factors Affect Healthy Aging (The Chicago Healthy Aging Study [CHAS]) (CHAS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00626379
Recruitment Status : Unknown
Verified February 2015 by Martha Daviglus, Northwestern University.
Recruitment status was:  Active, not recruiting
First Posted : February 29, 2008
Last Update Posted : March 2, 2015
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Martha Daviglus, Northwestern University

Brief Summary:
Heart disease is the leading cause of death in the United States and is responsible for 30% of all deaths in the United States. This study will examine how risk factors for heart disease in young and middle aged people affect people's health as they grow older.

Condition or disease
Coronary Disease Cardiovascular Diseases

Detailed Description:

Heart disease, including coronary heart disease (CHD) and cardiovascular disease (CVD), is a serious health problem in the United States. It is the leading cause of death in this country, and each year almost 700,000 people die from the disease. Risk factors for heart disease include high blood pressure, high cholesterol levels, tobacco use, diabetes, and history of a prior heart attack. It has been shown that young and middle aged adults with few risk factors experience a lower incidence of heart disease, lower Medicare costs, and longer lives than those with more risk factors. However, it is not known how having a low risk for heart disease at a young age affects health-related outcomes in older age. It may be possible that a low risk for developing heart disease in younger years results in healthier aging than does a higher risk. This study will examine former participants of the Chicago Heart Association (CHA) study who are now 65 to 84 years old. The purpose of this study is to determine how risk factors for heart disease in young adulthood and middle age are related to healthy aging.

This study will enroll 1500 people who participated in the CHA study from 1967 to 1973 and who are still living in the Greater Chicagoland area. Six hundred former participants who had a low risk of developing heart disease and 900 former participants who had a high risk of developing heart disease will be enrolled. Participants will attend one study visit that will include medical history interviews and questionnaires, a physical examination, blood pressure measurements, blood and urine collection, and an electrocardiogram (ECG) to measure the electrical activity of the heart. Blood samples will be collected and stored for future genetic testing. Participants will undergo physical functioning performance tests on balance, leg strength and coordination, grip strength, and endurance. They will also undergo a computed tomography chest scan to measure the amount of calcium in the arteries of the heart and ultrasound scans of the arteries in the neck to measure artery size and function.

Study Type : Observational
Actual Enrollment : 1395 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Low CV Risk, Ages 25-44 & CV/Non-CV Outcomes, Ages 65+
Study Start Date : November 2007
Actual Primary Completion Date : August 2010
Estimated Study Completion Date : December 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Diseases

Primary Outcome Measures :
  1. Subclinical atherosclerosis, CVD-related markers of inflammation, and levels of physical performance [ Time Frame: Measured during participant's one (baseline) study visit ]

Biospecimen Retention:   Samples With DNA
Whole blood, serum, white cells, and urine

Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years to 84 Years   (Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Original participants in the Chicago Heart Association (CHA) Detection in Industry study (1967 to 1973) who still reside in the Greater Chicagoland area.

Inclusion Criteria:

  • Participated in the CHA study
  • Lives in the Greater Chicagoland area

Exclusion Criteria:

  • Severely ill, disabled, or cognitively impaired

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00626379

United States, Illinois
Preventive Medicine Research Clinic
Chicago, Illinois, United States, 60611
Sponsors and Collaborators
Northwestern University
National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: Martha L. Daviglus, MD, PhD Northwestern University Feinberg School of Medicine

Responsible Party: Martha Daviglus, Adjunct Professor in Preventive Medicine and Medicine-General Internal Medicine and Geriatrics, Northwestern University Identifier: NCT00626379     History of Changes
Other Study ID Numbers: 1379
R01HL081141-04 ( U.S. NIH Grant/Contract )
First Posted: February 29, 2008    Key Record Dates
Last Update Posted: March 2, 2015
Last Verified: February 2015

Keywords provided by Martha Daviglus, Northwestern University:
Coronary Heart Disease
Subclinical Atherosclerosis
CVD-Related Markers of Inflammation

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Vascular Diseases
Arterial Occlusive Diseases