Examining How Heart Disease Risk Factors Affect Healthy Aging (The Chicago Healthy Aging Study [CHAS]) (CHAS)
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|ClinicalTrials.gov Identifier: NCT00626379|
Recruitment Status : Unknown
Verified February 2015 by Martha Daviglus, Northwestern University.
Recruitment status was: Active, not recruiting
First Posted : February 29, 2008
Last Update Posted : March 2, 2015
|Condition or disease|
|Coronary Disease Cardiovascular Diseases|
Heart disease, including coronary heart disease (CHD) and cardiovascular disease (CVD), is a serious health problem in the United States. It is the leading cause of death in this country, and each year almost 700,000 people die from the disease. Risk factors for heart disease include high blood pressure, high cholesterol levels, tobacco use, diabetes, and history of a prior heart attack. It has been shown that young and middle aged adults with few risk factors experience a lower incidence of heart disease, lower Medicare costs, and longer lives than those with more risk factors. However, it is not known how having a low risk for heart disease at a young age affects health-related outcomes in older age. It may be possible that a low risk for developing heart disease in younger years results in healthier aging than does a higher risk. This study will examine former participants of the Chicago Heart Association (CHA) study who are now 65 to 84 years old. The purpose of this study is to determine how risk factors for heart disease in young adulthood and middle age are related to healthy aging.
This study will enroll 1500 people who participated in the CHA study from 1967 to 1973 and who are still living in the Greater Chicagoland area. Six hundred former participants who had a low risk of developing heart disease and 900 former participants who had a high risk of developing heart disease will be enrolled. Participants will attend one study visit that will include medical history interviews and questionnaires, a physical examination, blood pressure measurements, blood and urine collection, and an electrocardiogram (ECG) to measure the electrical activity of the heart. Blood samples will be collected and stored for future genetic testing. Participants will undergo physical functioning performance tests on balance, leg strength and coordination, grip strength, and endurance. They will also undergo a computed tomography chest scan to measure the amount of calcium in the arteries of the heart and ultrasound scans of the arteries in the neck to measure artery size and function.
|Study Type :||Observational|
|Actual Enrollment :||1395 participants|
|Official Title:||Low CV Risk, Ages 25-44 & CV/Non-CV Outcomes, Ages 65+|
|Study Start Date :||November 2007|
|Actual Primary Completion Date :||August 2010|
|Estimated Study Completion Date :||December 2016|
- Subclinical atherosclerosis, CVD-related markers of inflammation, and levels of physical performance [ Time Frame: Measured during participant's one (baseline) study visit ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00626379
|United States, Illinois|
|Preventive Medicine Research Clinic|
|Chicago, Illinois, United States, 60611|
|Principal Investigator:||Martha L. Daviglus, MD, PhD||Northwestern University Feinberg School of Medicine|