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Examining How Heart Disease Risk Factors Affect Healthy Aging (The Chicago Healthy Aging Study [CHAS]) (CHAS)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2015 by Northwestern University.
Recruitment status was:  Active, not recruiting
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Martha Daviglus, Northwestern University Identifier:
First received: February 27, 2008
Last updated: February 27, 2015
Last verified: February 2015
Heart disease is the leading cause of death in the United States and is responsible for 30% of all deaths in the United States. This study will examine how risk factors for heart disease in young and middle aged people affect people's health as they grow older.

Coronary Disease
Cardiovascular Diseases

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Low CV Risk, Ages 25-44 & CV/Non-CV Outcomes, Ages 65+

Resource links provided by NLM:

Further study details as provided by Northwestern University:

Primary Outcome Measures:
  • Subclinical atherosclerosis, CVD-related markers of inflammation, and levels of physical performance [ Time Frame: Measured during participant's one (baseline) study visit ]

Biospecimen Retention:   Samples With DNA
Whole blood, serum, white cells, and urine

Enrollment: 1395
Study Start Date: November 2007
Estimated Study Completion Date: December 2016
Primary Completion Date: August 2010 (Final data collection date for primary outcome measure)
Detailed Description:

Heart disease, including coronary heart disease (CHD) and cardiovascular disease (CVD), is a serious health problem in the United States. It is the leading cause of death in this country, and each year almost 700,000 people die from the disease. Risk factors for heart disease include high blood pressure, high cholesterol levels, tobacco use, diabetes, and history of a prior heart attack. It has been shown that young and middle aged adults with few risk factors experience a lower incidence of heart disease, lower Medicare costs, and longer lives than those with more risk factors. However, it is not known how having a low risk for heart disease at a young age affects health-related outcomes in older age. It may be possible that a low risk for developing heart disease in younger years results in healthier aging than does a higher risk. This study will examine former participants of the Chicago Heart Association (CHA) study who are now 65 to 84 years old. The purpose of this study is to determine how risk factors for heart disease in young adulthood and middle age are related to healthy aging.

This study will enroll 1500 people who participated in the CHA study from 1967 to 1973 and who are still living in the Greater Chicagoland area. Six hundred former participants who had a low risk of developing heart disease and 900 former participants who had a high risk of developing heart disease will be enrolled. Participants will attend one study visit that will include medical history interviews and questionnaires, a physical examination, blood pressure measurements, blood and urine collection, and an electrocardiogram (ECG) to measure the electrical activity of the heart. Blood samples will be collected and stored for future genetic testing. Participants will undergo physical functioning performance tests on balance, leg strength and coordination, grip strength, and endurance. They will also undergo a computed tomography chest scan to measure the amount of calcium in the arteries of the heart and ultrasound scans of the arteries in the neck to measure artery size and function.


Ages Eligible for Study:   65 Years to 84 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Original participants in the Chicago Heart Association (CHA) Detection in Industry study (1967 to 1973) who still reside in the Greater Chicagoland area.

Inclusion Criteria:

  • Participated in the CHA study
  • Lives in the Greater Chicagoland area

Exclusion Criteria:

  • Severely ill, disabled, or cognitively impaired
  Contacts and Locations
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Please refer to this study by its identifier: NCT00626379

United States, Illinois
Preventive Medicine Research Clinic
Chicago, Illinois, United States, 60611
Sponsors and Collaborators
Northwestern University
National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: Martha L. Daviglus, MD, PhD Northwestern University Feinberg School of Medicine
  More Information

Responsible Party: Martha Daviglus, Adjunct Professor in Preventive Medicine and Medicine-General Internal Medicine and Geriatrics, Northwestern University Identifier: NCT00626379     History of Changes
Other Study ID Numbers: 1379
R01HL081141-04 ( US NIH Grant/Contract Award Number )
Study First Received: February 27, 2008
Last Updated: February 27, 2015

Keywords provided by Northwestern University:
Coronary Heart Disease
Subclinical Atherosclerosis
CVD-Related Markers of Inflammation

Additional relevant MeSH terms:
Cardiovascular Diseases
Heart Diseases
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Vascular Diseases
Arterial Occlusive Diseases processed this record on April 25, 2017