This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Aortic Dimensions in Turner Syndrome

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2008 by University of Aarhus.
Recruitment status was:  Active, not recruiting
Information provided by:
University of Aarhus Identifier:
First received: February 19, 2008
Last updated: February 27, 2008
Last verified: February 2008
An observational study of 102 women with Turner syndrome followed for 6 years with a two-yearly examination including ECHO, MRI of the heart and 24 ambulatory blood pressure. It has been found that besides an significantly increased risk of congenital cardiac malformations, TS have an increased risk of developing cardiac disease including the life threatening condition of aortic dilatation and rupture. The aim of the study is to describe the cardiac conditions of TS, evaluate different methods of examination and identify possible risc factors.

Turner Syndrome

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Aortic Dimensions, 24hour Ambulatory Blood Pressure and Sympathovagal Tone in Turner Syndrome. In Relation to Aortic Dilatation and Dissection.

Resource links provided by NLM:

Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • Aortic diameter at 3 well-defined levels measured by MRI and ECHO [ Time Frame: 2-yearly for 6 years ]

Secondary Outcome Measures:
  • 24hour ambulatory blood pressure [ Time Frame: 24h 2-yearly for 6 years ]

Biospecimen Retention:   Samples With DNA
Blood samples

Enrollment: 102
Study Start Date: August 2003
Estimated Study Completion Date: June 2012
Estimated Primary Completion Date: June 2012 (Final data collection date for primary outcome measure)
women with Turner syndrome
Control women


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Recrutted from hospital clinics and through the patient organisation

Inclusion Criteria:

  • Turner syndrome
  • Age 18-70 years

Exclusion Criteria:

  • Extreme adipositas
  • Contraindications to a MRI scan
  • Malignant disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

No Contacts or Locations Provided
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Professor Jens Sandahl Christiansen, Aarhus University Hospital, Aarhus, Denmark Identifier: NCT00624949     History of Changes
Other Study ID Numbers: 20010248
Study First Received: February 19, 2008
Last Updated: February 27, 2008

Keywords provided by University of Aarhus:
Turner syndrome
aortic dimensions
blood pressure
aortic dilatation
aortic rupture

Additional relevant MeSH terms:
Turner Syndrome
Gonadal Dysgenesis
Primary Ovarian Insufficiency
Pathologic Processes
Disorders of Sex Development
Urogenital Abnormalities
Sex Chromosome Disorders of Sex Development
Heart Defects, Congenital
Cardiovascular Abnormalities
Cardiovascular Diseases
Heart Diseases
Congenital Abnormalities
Sex Chromosome Disorders
Chromosome Disorders
Genetic Diseases, Inborn
Gonadal Disorders
Endocrine System Diseases
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female processed this record on August 17, 2017