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VLDL-triglyceride Under Acute Hyperinsulinaemia

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ClinicalTrials.gov Identifier: NCT00624104
Recruitment Status : Completed
First Posted : February 26, 2008
Last Update Posted : November 7, 2011
Sponsor:
Information provided by (Responsible Party):
University of Aarhus

Brief Summary:
The purpose of the study is to investigate and compare the lipid metabolism in lean and obese individuals. We want to investigate the effect of postprandial hyperinsulinaemia on VLDL-triglyceride metabolism

Condition or disease Intervention/treatment
Obesity Dietary Supplement: Food (fat free meal)

Study Type : Observational
Actual Enrollment : 16 participants
Official Title: VLDL-triglyceride Under Acute Hyperinsulinaemia
Study Start Date : March 2008
Actual Primary Completion Date : December 2010
Actual Study Completion Date : December 2010

Group/Cohort Intervention/treatment
1
Lean male
Dietary Supplement: Food (fat free meal)
Fat free meal (40% of REE)

2
Males with type 2 diabetes
Dietary Supplement: Food (fat free meal)
Fat free meal (40% of REE)




Primary Outcome Measures :
  1. VLDL metabolism [ Time Frame: Few hours ]

Biospecimen Retention:   Samples With DNA
specimen of muscle specimen of adipose tissue


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Ages Eligible for Study:   20 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Males with diabetes from departments out-patient clinic. Control group of healthyt volunteers
Criteria

Inclusion Criteria:

- Written consent

Exclusion Criteria:

  • Known diseases
  • Alcohol abuse
  • Smoker
  • Regular use of medicine

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00624104


Locations
Denmark
Department of Endocrinology M, Aarhus Hospital
Aarhus C, Denmark, 8000
Sponsors and Collaborators
University of Aarhus

Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT00624104     History of Changes
Other Study ID Numbers: ES-0001
First Posted: February 26, 2008    Key Record Dates
Last Update Posted: November 7, 2011
Last Verified: November 2011

Keywords provided by University of Aarhus:
VLDL
Kinetics
Hyperinsulinaemia
Obesity

Additional relevant MeSH terms:
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases