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VLDL-triglyceride Under Acute Hyperinsulinaemia

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00624104
First Posted: February 26, 2008
Last Update Posted: November 7, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
University of Aarhus
  Purpose
The purpose of the study is to investigate and compare the lipid metabolism in lean and obese individuals. We want to investigate the effect of postprandial hyperinsulinaemia on VLDL-triglyceride metabolism

Condition Intervention
Obesity Dietary Supplement: Food (fat free meal)

Study Type: Observational
Official Title: VLDL-triglyceride Under Acute Hyperinsulinaemia

Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • VLDL metabolism [ Time Frame: Few hours ]

Biospecimen Retention:   Samples With DNA
specimen of muscle specimen of adipose tissue

Enrollment: 16
Study Start Date: March 2008
Study Completion Date: December 2010
Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
1
Lean male
Dietary Supplement: Food (fat free meal)
Fat free meal (40% of REE)
2
Males with type 2 diabetes
Dietary Supplement: Food (fat free meal)
Fat free meal (40% of REE)

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 65 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Males with diabetes from departments out-patient clinic. Control group of healthyt volunteers
Criteria

Inclusion Criteria:

- Written consent

Exclusion Criteria:

  • Known diseases
  • Alcohol abuse
  • Smoker
  • Regular use of medicine
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00624104


Locations
Denmark
Department of Endocrinology M, Aarhus Hospital
Aarhus C, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
  More Information

Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT00624104     History of Changes
Other Study ID Numbers: ES-0001
First Submitted: February 18, 2008
First Posted: February 26, 2008
Last Update Posted: November 7, 2011
Last Verified: November 2011

Keywords provided by University of Aarhus:
VLDL
Kinetics
Hyperinsulinaemia
Obesity

Additional relevant MeSH terms:
Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases