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The Effect of Cataract Extraction on the Contractility of Ciliary Muscle

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2006 by Samsung Medical Center.
Recruitment status was:  Enrolling by invitation
Information provided by:
Samsung Medical Center Identifier:
First received: February 18, 2008
Last updated: NA
Last verified: May 2006
History: No changes posted
The purpose of this study is to investigate the changes in the pilocarpine-induced ciliary body movement before and after cataract extraction in order to determine the effect of lens sclerosis on the ciliary muscle contractility.

Condition Intervention
Other: UBM with pilocarpine in presbyopia

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Double Blind (Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: The Effect of Cataract Extraction on the Contractility of Ciliary Muscle

Resource links provided by NLM:

Further study details as provided by Samsung Medical Center:

Primary Outcome Measures:
  • ultrasound biomicroscopic findings (ciliary body axial length) [ Time Frame: 2 months before and after surgery ]

Enrollment: 15
Study Start Date: May 2006
Estimated Study Completion Date: March 2008
Estimated Primary Completion Date: March 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
ultrasound biomicrocopic examinations and pilocarpine instillation
Other: UBM with pilocarpine in presbyopia
ultrasound biomicroscopic examination in both eyes 30 minutes after one drop of 2% pilocarpine hydrochloride (Ocucarpine®, Samil Pharm., Seoul, Korea) instillation before and two months after cataract surgery
Other Name: UBM with pilocarpine

Detailed Description:
The functional changes in the ciliary body in presbyopia are not only important in a study of the mechanism for presbyopia but are also a key to various procedures or devices used to restore accommodation. Therefore, it is becoming increasingly important to quantify the in vivo accommodative changes in the aging ciliary muscle with and without a lens. We are going to evaluate the changes in the pilocarpine-induced contractility of the ciliary muscle in eyes with presbyopia before and after cataract extraction using ultrasound biomicroscopy (UBM).UBM will be performed with and without instilling 2 % pilocarpine, as well as before and 2 months after cataract extraction. Images of the ciliary body will be compared visually using Adobe Photoshop 7.0.

Ages Eligible for Study:   55 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Age : same or more than 55 years
  • Patients with senile cataract who are going to get cataract surgery

Exclusion Criteria:

  • Age : less than 55 years
  • Previous ocular disease other than cataract.
  Contacts and Locations
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Please refer to this study by its identifier: NCT00624039

Korea, Republic of
Samsung Medical Center
Seoul, Korea, Republic of, 135-710
Sponsors and Collaborators
Samsung Medical Center
Study Director: Changwon Kee, M.D. Department of Ophthalmology, Samsung Medical Center, Ilwon-dong, Kangnam-gu, Seoul, 135-710, Republic of Korea. E-mail:
  More Information

Responsible Party: Changwon Kee, Department of Ophthalmology, Samsung Medical Center, Seoul, Korea Identifier: NCT00624039     History of Changes
Other Study ID Numbers: CB2006
Study First Received: February 18, 2008
Last Updated: February 18, 2008

Keywords provided by Samsung Medical Center:

Additional relevant MeSH terms:
Lens Diseases
Eye Diseases
Refractive Errors
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Muscarinic Agonists
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action processed this record on April 25, 2017