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Early Infectious Disease Consultations in Staphylococcus Aureus Bacteremia

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2014 by National University Hospital, Singapore.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
Medicine, National University Hospital, Singapore Identifier:
First received: February 13, 2008
Last updated: January 6, 2014
Last verified: January 2014
The primary objective is to determine if early infectious disease (ID) consultation (defined as within 48 hours of a positive blood culture) will reduce mortality rates from Staphylococcus aureus bacteremia (SAB). This study will also determine if such consultations could reduce the duration of hospitalisation, recurrence and financial costs in patients with this infection.

Condition Intervention
Staphylococcus Aureus Bacteremia
Other: infectious disease specialist consultation

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Health Services Research
Official Title: Early Infectious Disease Consultation for Better Outcomes From Staphylococcus Aureus Bacteremia

Resource links provided by NLM:

Further study details as provided by National University Hospital, Singapore:

Primary Outcome Measures:
  • mortality [ Time Frame: 1 year ]

Secondary Outcome Measures:
  • recurrence [ Time Frame: 2 year ]
  • duration of hospitalisation [ Time Frame: 1 year ]
  • financial costs of hospitalisation [ Time Frame: 1 year ]

Estimated Enrollment: 200
Study Start Date: October 2007
Estimated Study Completion Date: December 2015
Estimated Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: ID
Patients receiving an early Infectious disease consultation ( within first 48 hours of a positive blood culture)
Other: infectious disease specialist consultation
Randomised trial to determine the utility of an early Infectious disease Consultation in Staphylococcus aureus bacteremic patients ( in the first 48 hours of a positive blood culture)
Other Name: Health Services
No Intervention: NO ID
Includes those patients who do not receive an Infectious disease consultation in the first 48 hours

Detailed Description:

Bacteremia is a serious manifestation of Staphylococcus aureus infection with an attributable mortality as high as 25% in MRSA bacteremia. More than a third of patients end up with complications such as endocarditis, osteomyelitis or pneumonia.

Overall the outcome of patients with respect to mortality or recurrence is better in patients who have an eradicable focus and have received an appropriate antibiotic dose and duration. Also complicated bacteremia is more common in patients with

  • persistent bacteremia or fever
  • prosthetic device
  • new murmur
  • skin findings of a systemic infection

Based on this evidence, an ID consultation could improve the outcomes of patients with SAB by

  • Advising adequate antibiotic dosage and duration
  • Sourcing out and counselling eradication of any focus of infection

Ages Eligible for Study:   1 Month and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • All inpatients at the National University Hospital with Staphylococcus aureus (both methicillin sensitive and methicillin resistant) bacteremia isolated within the defined time period

Exclusion Criteria:

  • Patients who died or were discharged before the notification from the laboratory
  • Neonates
  • Polymicrobial bacteremia
  Contacts and Locations
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Please refer to this study by its identifier: NCT00622882

Contact: Paul A Tambyah, MD (65)67724375

National University Hospital Recruiting
Singapore, Singapore, 11974
Contact: Paul A Tambyah, Dip ABIM    (65)67724375   
Principal Investigator: Paul A Tambyah, Dip ABIM         
Sponsors and Collaborators
National University Hospital, Singapore
Principal Investigator: Paul A Tambyah, MD National University, Singapore
  More Information

Responsible Party: Medicine, Professor Paul Ananth Tambyah, National University Hospital, Singapore Identifier: NCT00622882     History of Changes
Other Study ID Numbers: DSRB-B/06/274
Study First Received: February 13, 2008
Last Updated: January 6, 2014

Keywords provided by National University Hospital, Singapore:
Staphylococcus aureus
Infectious Diseases specialists

Additional relevant MeSH terms:
Communicable Diseases
Bacterial Infections
Systemic Inflammatory Response Syndrome
Pathologic Processes processed this record on May 23, 2017