Arrhythmias in Myotonic Muscular Dystrophy (DM1)
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|ClinicalTrials.gov Identifier: NCT00622453|
Recruitment Status : Completed
First Posted : February 25, 2008
Last Update Posted : February 14, 2018
|Condition or disease||Intervention/treatment|
|Muscular Dystrophy Arrhythmia Sudden Cardiac Death||Other: Screening|
The long term objectives of this population study is a more defined natural history, optimal diagnostic testing methodology, and methods of therapy for arrhythmias in individuals with myotonic muscular dystrophy. The goal is a more adequate definition of appropriate diagnosis and therapy for arrhythmias in order to decrease the likelihood of cardiac morbidity and mortality in this disorder.
The specific aims of the study involve an initial survey of individuals with myotonic muscular dystrophy detailing multiple factors. Non-invasive electrocardiographic testing will be done. Using this initial data and subsequent follow-up data collected yearly the cohort of patients will be followed as to arrhythmia development over a minimum of five years and likely longer with a long-term registry and evaluation of National Death Records and Ancestry.com. This project is unique in that it characterizes a non-neurologic abnormality associated with a neuromuscular disease, myotonic muscular dystrophy.
|Study Type :||Observational|
|Actual Enrollment :||448 participants|
|Official Title:||A Registry of Arrhythmias in Myotonic Muscular Dystrophy|
|Study Start Date :||September 1996|
|Primary Completion Date :||January 2006|
|Study Completion Date :||February 2015|
Registry of Arrhythmias
Screening of individuals with myotonic muscular dystrophy to evaluate the utility of non-invasive electrocardiographic screening methods and history in predicting serious arrhythmic events.
Electrocardiography Blood Test
- Evaluate incidence of arrhythmias in myotonic muscular dystrophy [ Time Frame: 3 years ]
- Evaluate with diagnostic non-invasive electrocardiogram (ECG) [ Time Frame: 3 Years ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00622453
|United States, Indiana|
|Krannert Institute of Cardiology|
|Indianapolis, Indiana, United States, 46202|
|Principal Investigator:||William Groh, MD||Indiana School of Medicine|