Arrhythmias in Myotonic Muscular Dystrophy (DM1)
Recruitment status was Active, not recruiting
Adult myotonic muscular dystrophy (Steinert's disease) is the most common inherited neuromuscular disorder. Cardiac rhythm disturbances occur frequently in this disease state and may be responsible for up to one-third of deaths. In this study, we intend to evaluate the utility of non-invasive electrocardiographic screening methods and history in predicting serious arrhythmic events.
|Official Title:||A Registry of Arrhythmias in Myotonic Muscular Dystrophy|
- Evaluate incidence of arrhythmias in myotonic muscular dystrophy [ Time Frame: 3 years ] [ Designated as safety issue: No ]
- Evaluate with diagnostic non-invasive electrocardiogram (ECG) [ Time Frame: 3 Years ] [ Designated as safety issue: No ]
|Study Start Date:||September 1996|
|Estimated Study Completion Date:||December 2012|
|Primary Completion Date:||January 2006 (Final data collection date for primary outcome measure)|
Registry of Arrhythmias
Screening of individuals with myotonic muscular dystrophy to evaluate the utility of non-invasive electrocardiographic screening methods and history in predicting serious arrhythmic events.
Electrocardiography Blood Test
The long term objectives of this population study is a more defined natural history, optimal diagnostic testing methodology, and methods of therapy for arrhythmias in individuals with myotonic muscular dystrophy. The goal is a more adequate definition of appropriate diagnosis and therapy for arrhythmias in order to decrease the likelihood of cardiac morbidity and mortality in this disorder.
The specific aims of the study involve an initial survey of individuals with myotonic muscular dystrophy detailing multiple factors. Non-invasive electrocardiographic testing will be done. Using this initial data and subsequent follow-up data collected yearly the cohort of patients will be followed as to arrhythmia development over a minimum of five years and likely longer with a long-term registry and evaluation of National Death Records and Ancestry.com. This project is unique in that it characterizes a non-neurologic abnormality associated with a neuromuscular disease, myotonic muscular dystrophy.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00622453
|United States, Indiana|
|Krannert Institute of Cardiology|
|Indianapolis, Indiana, United States, 46202|
|Principal Investigator:||William Groh, MD||Indiana School of Medicine|