Dose Range Study of Anamorelin in Patients With Non-small Cell Lung Cancer
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The purpose of this study is to evaluate doses of anamorelin for safety and efficacy in patients with non-small cell lung cancer.
Condition or disease
Carcinoma, Non-Small-Cell Lung
Drug: anamorelin HClDrug: placebo
Cancer cachexia is a devastating, often late-stage complication of an underlying malignancy. Despite the significant importance of cancer-related cachexia, treatments are lacking and there are no products approved for this indication. Anamorelin HCl, by virtue of its ghrelin agonist activity, may serve a role in the treatment of cancer cachexia. This placebo controlled dose range study will evaluate the safety and efficacy of anamorelin HCl in patients with non-small cell lung cancer, a cancer associated with a high prevalence of cachexia.
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Ages Eligible for Study:
18 Years to 85 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
stage IIIB or IV NSCLC
eligible for treatment of NSCLC with paclitaxel and carboplatin +/- bevacizumab
mixed large and small cell histologies for lung cancer