Genetics of Schizophrenia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00619437
Recruitment Status : Unknown
Verified February 2008 by Sheba Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : February 21, 2008
Last Update Posted : February 21, 2008
Information provided by:
Sheba Medical Center

Brief Summary:
Genetic etiology in schizophrenia is widely accepted. However, many chromosomal sites were shown to characterize the families of patients with schizophrenia. This is probably due to the high genetic heterogenity of this illness. Thus, it is important to investigate the genetic factor in relatively genetically homogenous populations. Many studies have indicate that Ashkenazy Jews show relative gentic homogenity. Indeed, the genes responsible for most Mendelian disorders of Jewish peoples have been identified. The study will apply genome-wide mutation screening methods to identify candidate allells in subjects of Ashkenazi Jewish ancestry with multiplex schizophrenia.

Condition or disease

Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Family-Based
Time Perspective: Prospective
Official Title: Genetics of Schizophrenia
Study Start Date : April 2008
Estimated Study Completion Date : December 2009

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Schizophrenia

Biospecimen Retention:   Samples With DNA
Cell Lines / DNA

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 78 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Inclusion Criteria:

  1. Age 18+;
  2. Meet DSM-IV criteria for Schizophrenia;
  3. At least one first-degree relative who Meet DSM-IV criteria for Schizophrenia;
  4. Can sign the informed consent form.

Exclusion Criteria:

  1. Patients suffering from terminal or incurabale disease;
  2. Minors, incompetents

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00619437

Contact: Raz Gross, MD, MPH 972 3 530 3962

Sheba Medical Center Not yet recruiting
Tel Hashomer, Israel
Contact: Michael Bunzel, MD         
Principal Investigator: Michael Bunzel, MD         
Sponsors and Collaborators
Sheba Medical Center
Study Director: Michael Bunzel, MD Psychiatric ward, Sheba Medical Center

Responsible Party: Raz Gross, Head, Mental Health Epidemiology, The Gertner Institute for Epidemiology Identifier: NCT00619437     History of Changes
Other Study ID Numbers: SHEBA-07-4620-RG-CTIL
First Posted: February 21, 2008    Key Record Dates
Last Update Posted: February 21, 2008
Last Verified: February 2008

Keywords provided by Sheba Medical Center:

Additional relevant MeSH terms:
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders