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Steroid Before Thyroidectomy

This study has been completed.
Information provided by:
University of Bern Identifier:
First received: February 7, 2008
Last updated: June 6, 2008
Last verified: June 2008
We evaluated the effects of giving a single dose of steroid before thyroid surgery in a single institutional, double-blinded, randomized controlled trial. Postoperative nausea, pain, and vocal function were significantly improved after steroid administration compared to controls.

Condition Intervention
Thyroid Surgery for Benign Disease Drug: Dexamethason Helvepharm ® Drug: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Official Title: Does a Single Dose of Steroid Before Thyroidectomy Improve Postoperative Nausea, Pain and Vocal Function?

Resource links provided by NLM:

Further study details as provided by University of Bern:

Primary Outcome Measures:
  • Nausea [ Time Frame: 0-72 hours postoperative ]

Secondary Outcome Measures:
  • Pain, vocal function [ Time Frame: 0-72 hours postoperative ]

Enrollment: 72
Study Start Date: November 2005
Study Completion Date: June 2007
Arms Assigned Interventions
Placebo Comparator: A, 1
Placebo 45 minutes prior to surgery
Drug: Placebo
100 ml sodium chloride i.v. 45 minutes prior to surgery
Active Comparator: A, 2
8 mg Dexamethasone 45 minutes prior to surgery
Drug: Dexamethason Helvepharm ®
8 mg Dexamethason i.v. 45 minutes prior to surgery


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients undergoing thyroid surgery for benign disease

Exclusion Criteria:

  • Depression
  • Chronic pain disorder
  • Insulin dependent diabetes mellitus
  • History of PONV
  • Pregnancy
  • Age < 18 years
  • Received antiemetic therapy within 48 hours
  Contacts and Locations
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Please refer to this study by its identifier: NCT00619086

Department of visceral- and transplant surgery
Bern, Switzerland, 3010
Sponsors and Collaborators
University of Bern
Principal Investigator: Stephan A. Vorburger, MD Dept of visceral- and transplant surgery, University Hospital Bern
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Candinas Daniel, MD, Department of Visceral- and Transplantation Surgery Identifier: NCT00619086     History of Changes
Other Study ID Numbers: KEK_49_05
Study First Received: February 7, 2008
Last Updated: June 6, 2008

Keywords provided by University of Bern:
nausea processed this record on August 22, 2017