We updated the design of this site on September 25th. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Steroid Before Thyroidectomy

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00619086
First Posted: February 20, 2008
Last Update Posted: June 9, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of Bern
  Purpose
We evaluated the effects of giving a single dose of steroid before thyroid surgery in a single institutional, double-blinded, randomized controlled trial. Postoperative nausea, pain, and vocal function were significantly improved after steroid administration compared to controls.

Condition Intervention
Thyroid Surgery for Benign Disease Drug: Dexamethason Helvepharm ® Drug: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Official Title: Does a Single Dose of Steroid Before Thyroidectomy Improve Postoperative Nausea, Pain and Vocal Function?

Resource links provided by NLM:


Further study details as provided by University of Bern:

Primary Outcome Measures:
  • Nausea [ Time Frame: 0-72 hours postoperative ]

Secondary Outcome Measures:
  • Pain, vocal function [ Time Frame: 0-72 hours postoperative ]

Enrollment: 72
Study Start Date: November 2005
Study Completion Date: June 2007
Arms Assigned Interventions
Placebo Comparator: A, 1
Placebo 45 minutes prior to surgery
Drug: Placebo
100 ml sodium chloride i.v. 45 minutes prior to surgery
Active Comparator: A, 2
8 mg Dexamethasone 45 minutes prior to surgery
Drug: Dexamethason Helvepharm ®
8 mg Dexamethason i.v. 45 minutes prior to surgery

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients undergoing thyroid surgery for benign disease

Exclusion Criteria:

  • Depression
  • Chronic pain disorder
  • Insulin dependent diabetes mellitus
  • History of PONV
  • Pregnancy
  • Age < 18 years
  • Received antiemetic therapy within 48 hours
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00619086


Locations
Switzerland
Department of visceral- and transplant surgery
Bern, Switzerland, 3010
Sponsors and Collaborators
University of Bern
Investigators
Principal Investigator: Stephan A. Vorburger, MD Dept of visceral- and transplant surgery, University Hospital Bern
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Candinas Daniel, MD, Department of Visceral- and Transplantation Surgery
ClinicalTrials.gov Identifier: NCT00619086     History of Changes
Other Study ID Numbers: KEK_49_05
First Submitted: February 7, 2008
First Posted: February 20, 2008
Last Update Posted: June 9, 2008
Last Verified: June 2008

Keywords provided by University of Bern:
thyroidectomy
dexamethasone
steroid
nausea