AV Nodal Reentrant Tachycardia Study (AVNRT)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00618683|
Recruitment Status : Recruiting
First Posted : February 20, 2008
Last Update Posted : April 11, 2018
|Condition or disease||Intervention/treatment||Phase|
|Tachycardia, Atrioventricular Nodal Reentry||Procedure: Cardiac Invasive Electrophysiological Study||Not Applicable|
- The Tendon of Todaro forms a line of block during slow/fast AVNRT preventing the atrial impulse from entering the triangle of Koch (and perhaps providing sufficient time for activation to pass through the coronary sinus coat to activate the posterior extensions of the AV node as is critical to maintenance of tachycardia)
- The coronary sinus myocardial coat participates in all of the forms of AVNRT. The reentrant circuit is thus not confined within the triangle of Koch and sites remote from the compact AV node could be targeted for ablation reducing the risk of AV conduction block.
- A model of the reentrant circuit can be created for each patient's tachycardia, using the site of earliest retrograde activation to suggest the retrograde limb and the resetting response to suggest the anterograde limb.
Resetting and Mapping of AV nodal reentrant tachycardia:
Pacing will be analyzed to see at which sites, the tachycardia can be reset by the latest extra-stimuli (i.e., with the least advancement in local activation). The coupling interval will be compared to the latest extra-stimulus capable of resetting (advancing) the tachycardia from the postero-septal tricuspid annulus.
The patients will act as their own reference, since the standard ablation technique in the postero-septal space is being performed first and tested for efficacy. The McNemar test will be applied to compare the efficacy of ablation at the postero-septal tricuspid annulus alone (standard ablation), with the efficacy of this ablation plus ablation within the coronary sinus. From our initial observations, It is anticipated that the additional ablation in the coronary sinus will increase the efficacy of the procedure from <95% to >98%, such that 100 cases should provide sufficient data to reach statistical significance.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||100 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Localization of the Anterograde and Retrograde Components of the Reentrant Circuit of AV Nodal Reentrant Tachycardia|
|Study Start Date :||March 2004|
|Estimated Primary Completion Date :||March 2020|
|Estimated Study Completion Date :||March 2020|
Mapping and Ablation
Procedure: Cardiac Invasive Electrophysiological Study
Mapping and localizing of the components of the reentrant circuit as part of the Electrophysiological Study
- raise the frequency of success to more than 98% [ Time Frame: unk ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00618683
|Contact: Deborah Lockwood, M.D.||405-271 9696 ext firstname.lastname@example.org|
|Contact: Karrie Meeks, BS ESE, CCRP||405-271-9696 ext email@example.com|
|United States, Oklahoma|
|The University of Oklahoma Health Sciences Center||Recruiting|
|Oklahoma City, Oklahoma, United States, 73104|
|Contact: Karrie Meeks, BS ESE, CCRP 405-271-9696 ext 37520 firstname.lastname@example.org|
|Principal Investigator: Deborah Lockwood, M.D.|
|Principal Investigator:||Deborah Lockwood, M.D.||University of Oklahoma|