Inert Dusts and Pathology of Chronic Obstructive Pulmonary Disease

This study has been completed.

Sponsor:

Information provided by (Responsible Party):

Rolf Ziesche, Medical University of Vienna

ClinicalTrials.gov Identifier:

NCT00618137

First received: February 5, 2008

Last updated: August 23, 2012

Last verified: August 2012

History of Changes

Purpose

The main objective of the study is the exploration of the natural course of COPD and its biological background. To this end, active workers without COPD and workers in functional classes GOLD 0-III are investigated by a combined clinical and molecular approach. The study has been designed as a prospective, intraindividual pilot in 160 male or female volunteers of the greater Vienna Area over a period of three years for each individual volunteer.

Condition
Pulmonary Disease, Chronic Obstructive


Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Prospective
Official Title:	Longitudinal Assessment of Clinical and Molecular Pathology of Chronic Obstructive Lung Disease and the Possible Influence of Inert Dusts in Working Volunteers of the Greater Vienna Area

Resource links provided by NLM:

MedlinePlus related topics: COPD Lung Diseases

U.S. FDA Resources

Further study details as provided by Medical University of Vienna:

Biospecimen Retention: Samples With DNA

Transbronchial lung biopsies Blood serum


Enrollment:	160
Study Start Date:	January 2007
Study Completion Date:	December 2011
Primary Completion Date:	December 2011 (Final data collection date for primary outcome measure)

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Eligibility


Ages Eligible for Study:	18 Years to 65 Years (Adult)
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Probability Sample

Study Population

Community sample of workers from the greater Vienna area

Criteria

Inclusion Criteria:

COPD °0-III
Workers of the greater Vienna Area
Current smokers or ex-smokers

Exclusion Criteria:

COPD °IV
Bronchial asthma
Major cardiovascular diseases, in particular stroke and myocardial infarction with reduced cardiac function
Age > 65 years
Acute or chronic bronchial infection, in particular bronchiectasis
Cancer

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00618137

Locations


Austria
Department of Pulmonary Medicine, Medical University of Vienna
Vienna, Austria, A-1090

Sponsors and Collaborators

Medical University of Vienna

Investigators


Principal Investigator:	Lutz H Block, MD	Medical University of Vienna
Study Director:	Rolf Ziesche, MD	Medical University of Vienna

More Information


Responsible Party:	Rolf Ziesche, Associated Professor of Medicine, Medical University of Vienna
ClinicalTrials.gov Identifier:	NCT00618137 History of Changes
Other Study ID Numbers:	COPD-AUVA
Study First Received:	February 5, 2008
Last Updated:	August 23, 2012
Health Authority:	Austria: Ethikkommission

Keywords provided by Medical University of Vienna:


Chronic obstructive pulmonary disease Gene expression profiling Inert dusts Natural course Prospective assessment

Additional relevant MeSH terms:


Lung Diseases Lung Diseases, Obstructive Pulmonary Disease, Chronic Obstructive Chronic Disease	Respiratory Tract Diseases Disease Attributes Pathologic Processes

ClinicalTrials.gov processed this record on September 29, 2016

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