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Inert Dusts and Pathology of Chronic Obstructive Pulmonary Disease

This study has been completed.
Information provided by (Responsible Party):
Rolf Ziesche, Medical University of Vienna Identifier:
First received: February 5, 2008
Last updated: August 23, 2012
Last verified: August 2012
The main objective of the study is the exploration of the natural course of COPD and its biological background. To this end, active workers without COPD and workers in functional classes GOLD 0-III are investigated by a combined clinical and molecular approach. The study has been designed as a prospective, intraindividual pilot in 160 male or female volunteers of the greater Vienna Area over a period of three years for each individual volunteer.

Pulmonary Disease, Chronic Obstructive

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Longitudinal Assessment of Clinical and Molecular Pathology of Chronic Obstructive Lung Disease and the Possible Influence of Inert Dusts in Working Volunteers of the Greater Vienna Area

Resource links provided by NLM:

Further study details as provided by Rolf Ziesche, Medical University of Vienna:

Biospecimen Retention:   Samples With DNA
Transbronchial lung biopsies Blood serum

Enrollment: 160
Study Start Date: January 2007
Study Completion Date: December 2011
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
  Show Detailed Description


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Community sample of workers from the greater Vienna area

Inclusion Criteria:

  • COPD °0-III
  • Workers of the greater Vienna Area
  • Current smokers or ex-smokers

Exclusion Criteria:

  • COPD °IV
  • Bronchial asthma
  • Major cardiovascular diseases, in particular stroke and myocardial infarction with reduced cardiac function
  • Age > 65 years
  • Acute or chronic bronchial infection, in particular bronchiectasis
  • Cancer
  Contacts and Locations
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Please refer to this study by its identifier: NCT00618137

Department of Pulmonary Medicine, Medical University of Vienna
Vienna, Austria, A-1090
Sponsors and Collaborators
Medical University of Vienna
Principal Investigator: Lutz H Block, MD Medical University of Vienna
Study Director: Rolf Ziesche, MD Medical University of Vienna
  More Information

Responsible Party: Rolf Ziesche, Associated Professor of Medicine, Medical University of Vienna Identifier: NCT00618137     History of Changes
Other Study ID Numbers: COPD-AUVA
Study First Received: February 5, 2008
Last Updated: August 23, 2012

Keywords provided by Rolf Ziesche, Medical University of Vienna:
Chronic obstructive pulmonary disease
Gene expression profiling
Inert dusts
Natural course
Prospective assessment

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Chronic Disease
Respiratory Tract Diseases
Disease Attributes
Pathologic Processes processed this record on May 25, 2017