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Inert Dusts and Pathology of Chronic Obstructive Pulmonary Disease

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ClinicalTrials.gov Identifier: NCT00618137
Recruitment Status : Completed
First Posted : February 18, 2008
Last Update Posted : August 24, 2012
Sponsor:
Information provided by (Responsible Party):
Rolf Ziesche, Medical University of Vienna

Study Description
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Brief Summary:
The main objective of the study is the exploration of the natural course of COPD and its biological background. To this end, active workers without COPD and workers in functional classes GOLD 0-III are investigated by a combined clinical and molecular approach. The study has been designed as a prospective, intraindividual pilot in 160 male or female volunteers of the greater Vienna Area over a period of three years for each individual volunteer.

Condition or disease
Pulmonary Disease, Chronic Obstructive

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Study Design
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Study Type : Observational
Actual Enrollment : 160 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Longitudinal Assessment of Clinical and Molecular Pathology of Chronic Obstructive Lung Disease and the Possible Influence of Inert Dusts in Working Volunteers of the Greater Vienna Area
Study Start Date : January 2007
Actual Primary Completion Date : December 2011
Actual Study Completion Date : December 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: COPD Lung Diseases
U.S. FDA Resources

Groups and Cohorts
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information


Outcome Measures
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Biospecimen Retention:   Samples With DNA
Transbronchial lung biopsies Blood serum

Eligibility Criteria
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Community sample of workers from the greater Vienna area
Criteria

Inclusion Criteria:

  • COPD °0-III
  • Workers of the greater Vienna Area
  • Current smokers or ex-smokers

Exclusion Criteria:

  • COPD °IV
  • Bronchial asthma
  • Major cardiovascular diseases, in particular stroke and myocardial infarction with reduced cardiac function
  • Age > 65 years
  • Acute or chronic bronchial infection, in particular bronchiectasis
  • Cancer
Contacts and Locations
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00618137


Locations
Austria
Department of Pulmonary Medicine, Medical University of Vienna
Vienna, Austria, A-1090
Sponsors and Collaborators
Medical University of Vienna
Investigators
Principal Investigator: Lutz H Block, MD Medical University of Vienna
Study Director: Rolf Ziesche, MD Medical University of Vienna
More Information
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Responsible Party: Rolf Ziesche, Associated Professor of Medicine, Medical University of Vienna
ClinicalTrials.gov Identifier: NCT00618137     History of Changes
Other Study ID Numbers: COPD-AUVA
First Posted: February 18, 2008    Key Record Dates
Last Update Posted: August 24, 2012
Last Verified: August 2012

Keywords provided by Rolf Ziesche, Medical University of Vienna:
Chronic obstructive pulmonary disease
Gene expression profiling
Inert dusts
Natural course
Prospective assessment

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Chronic Disease
 Respiratory Tract Diseases
Disease Attributes
Pathologic Processes