Antihypertensive Response to Losartan and Genetic Polymorphisms
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|ClinicalTrials.gov Identifier: NCT00617877|
Recruitment Status : Completed
First Posted : February 18, 2008
Last Update Posted : July 22, 2009
|Condition or disease||Intervention/treatment||Phase|
|Hypertension||Drug: losartan potassium Drug: Comparator: Hydrochlorothiazide||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||800 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Pharmacogenetic of the Antihypertensive Response to the Angiotensin II Blockers in Monotherapy or Associated to Hydrochlorothiazide|
|Study Start Date :||March 2005|
|Actual Primary Completion Date :||June 2009|
|Actual Study Completion Date :||June 2009|
Losartan 50 mg/day for 4 weeks, then doubled to losartan 100 mg/day in case of BP more than 140/90 mm Hg. HCTZ 25 mg will be added at week 8 if BP is more than 140/90 mm Hg. This last regimen will be continued until the end of the study (visit 9-week 48).
Drug: losartan potassium
Losartan 50 mg/day for 4 weeks, then doubled to losartan 100 mg/day (in case of BP more than 140/90 mm Hg.) Continued until the end of the study (visit 9-week 48).Drug: Comparator: Hydrochlorothiazide
Hydrochlorothiazide 25 mg will be added at week 8 if BP is more than 140/90 mm Hg. This last regimen will be continued until the end of the study (visit 9-week 48).
- Blood pressure reduction with reference to genetic polymorphisms. [ Time Frame: Over 1 Year ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00617877
|Study Director:||Medical Monitor||Merck Sharp & Dohme Corp.|