Treatment of Postoperative Pain After Total Knee Arthroplasy Using Intravenous Lidocaine Infusion
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00616850|
Recruitment Status : Withdrawn (Orthopedic surgeon that does our knee surgeries moved to a different location)
First Posted : February 15, 2008
Last Update Posted : May 22, 2014
|Condition or disease||Intervention/treatment||Phase|
|Total Knee Arthroplasty||Procedure: Continuous femoral catheter block Drug: Lidocaine Other: Preservative free normal saline||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||0 participants|
|Intervention Model:||Factorial Assignment|
|Masking:||Triple (Participant, Care Provider, Investigator)|
|Official Title:||Treatment of Postoperative Pain After Total Knee Arthroplasty Using Intravenous Lidocaine Infusion in Combination With Patient Controlled Analgesia Versus Continuous Femoral Block Catheter in Combination With Patient Controlled Analgesia: A Prospective, Randomized, Double-Blinded, Placebo-Controlled Study.|
|Study Start Date :||October 2007|
|Actual Primary Completion Date :||July 2008|
|Actual Study Completion Date :||July 2009|
Active Comparator: Group A
Group A subjects will receive a continuous femoral block catheter and a Patient Controlled Analgesia (PCA).
Procedure: Continuous femoral catheter block
A constant infusion of ropivacaine 0.2% without epinephrine will be given to each subject via continuous femoral catheter in Group A.
Experimental: Group B
Group B subjects will receive a low dose lidocaine (1.33 mg/kg/hr) infusion and a Patient Controlled Analgesia.
Lidocaine 1.33mg/kg/hr continuous IV infusion following induction of general anesthesia to 24 hours postoperatively.
Placebo Comparator: Group C
Group C subjects will receive placebo (preservative free normal saline) infusion and a Patient Controlled Analgesia.
Other: Preservative free normal saline
Preservative free normal saline 1.33mg/kg/hr continuous IV infusion following induction of general anesthesia to 24 hours postoperatively.
- Total PCA opioid consumption [ Time Frame: 72 hours ]
- Time to first flatus [ Time Frame: 72 hours postoperatively ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00616850
|United States, California|
|Loma Linda University Medical Center|
|Loma Linda, California, United States, 92354|
|Principal Investigator:||Michelle Schlunt, M.D.||Loma Linda University Medical Center|