Physical Activity in the Treatment of Obesity (CHANGE)
|ClinicalTrials.gov Identifier: NCT00615238|
Recruitment Status : Completed
First Posted : February 14, 2008
Last Update Posted : September 28, 2017
Although exercise is widely regarded as a key component in obesity treatment, few individuals seem able to adhere to exercise programs over time. In response, efforts have focused on developing new approaches to physical activity that may appeal to sedentary overweight persons. For instance, is has been shown that accumulating multiple short bouts of vigorous exercise may enhance both exercise adherence and weight loss in overweight persons. Accumulating moderate-intensity activity throughout the day may offer comparable health and weight benefits as a traditional exercise program. Public health recommendations now include the option of accumulating 30 minutes of moderate-intensity lifestyle activity for health and well-being. While these two options offer a viable alternative to those who dislike or cannot sustain continuous vigorous exercise programs, it is unclear whether the flexibility of accumulating physical activity or the vigorous intensity of the exercise is responsible for improved weight loss and long-term adherence.
The goal of this research is to extend our preliminary findings suggesting that moderate intensity lifestyle activity is an important and viable alternative to traditional structured vigorous exercise for obese dieting individuals. The primary specific aim of this project is to compare the effects of three modes of exercise on long-term weight regain. Participants will be 165 overweight men and women who are sedentary, but otherwise healthy. All participants will receive the same 16-week behavioral weight loss program and will be randomized to one of three exercise study conditions: 1) diet-plus-continuous bouts of vigorous aerobic exercise; 2) diet-plus-short bouts of vigorous aerobic exercise accumulated throughout the day; or 3) diet-plus-moderate intensity lifestyle activity accumulated throughout the day. By varying both the intensity and duration of exercise bouts, we can determine which type of exercise is associated with optimal outcomes one year later. Additional questions of interest include:
- Does mode of exercise influence exercise adherence?
- Does mode of exercise improve cardiovascular risk profiles similarly in all three conditions?
- Does mode of exercise influence changes in body composition?
- Does mode of exercise influence exercise enjoyment and exercise self-efficacy?
|Condition or disease||Intervention/treatment||Phase|
|Obesity||Behavioral: Diet plus continuous bouts Behavioral: Diet plus short bouts Behavioral: Diet plus moderate lifestyle activity||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||177 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Physical Activity in the Treatment of Obesity: A Randomized Trial|
|Study Start Date :||April 2000|
|Actual Primary Completion Date :||March 2004|
|Actual Study Completion Date :||May 2004|
Experimental: Diet plus continuous bouts
diet-plus-continuous bouts of vigorous aerobic exercise
Behavioral: Diet plus continuous bouts
Patients consumed a 1200 kcal/d diet and were instructed to perform 4 30-60 minute aerobic workouts per week
Experimental: Diet plus short bouts
diet-plus-short bouts of vigorous aerobic exercise accumulated throughout the day
Behavioral: Diet plus short bouts
Patients consumed a 1200 kcal/d diet and were instructed to perform short 10 minutes bouts of aerobic exercise 4 times per week
Experimental: Diet plus moderate lifestyle activity
diet-plus-moderate intensity lifestyle activity accumulated throughout the day
Behavioral: Diet plus moderate lifestyle activity
Patients consumed a 1200 kcal/d diet and were instructed to accumulate moderate intensity physical activity on most days of the week.
- Participants were randomized to one of three diet and exercise study conditions. We were interested in which type of exercise is associated with optimal short- and long-term body composition changes. [ Time Frame: Baseline, Week-16, Week-68 ]
- Does mode of exercise improve cardiovascular risk profiles similarly in all three conditions? [ Time Frame: Baseline, week-16, week-68 ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00615238
|United States, Maryland|
|Johns Hopkins School of Medicine|
|Baltimore, Maryland, United States, 21224|
|Study Director:||Jeremey D Walston, MD||JHU School of Med|
|Study Director:||Susan J Bartlett, PhD||JHU School of Med|