Hypothalamo-, Pituitary-, Adrenal Axis Dysfunction in Subarachnoid Hemorrhage (SAHENDO)
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|ClinicalTrials.gov Identifier: NCT00614887|
Recruitment Status : Completed
First Posted : February 13, 2008
Last Update Posted : February 13, 2008
Subarachnoid haemorrhage (SAH) may cause damage to the hypotalamo-pituitary-adrenal axis (HPA) thus disturbing the hormonal response of these structures.
The aim of our study is to characterize the function of HPA-axis acutely and over time up to three months in patients with SAH.
|Condition or disease|
|Subarachnoid Hemorrhage Cerebral Aneurysm|
The hypotalamo-pituitary-adrenal (HPA)-axis may be affected in SAH by temporary or permanent damage to the hypothalamus and/or pituitary gland. Also surgery or endovascular treatment of a ruptured intracranial aneurysm may affect the hormonal response of the HPA-axis. Some data suggest a high incidence of delayed endocrine abnormalities in patients with SAH but only little data exists on the acute endocrine abnormalities in this disease.
We will study the pituitary-adrenal hormone levels in patients with acute aneurysmal SAH and patients admitted for elective cranial aneurysm surgery will serve as a control population. We will use serum free cortisol calculation and total cortisol measurements as well as adrenocorticotrophic hormone (ACTH) stimulation test in assessing the responsiveness of the adrenal gland to exogenous ACTH. The hormone levels will be measured repeatedly during the first seven days after SAH and once at three months.
|Study Type :||Observational|
|Actual Enrollment :||46 participants|
|Observational Model:||Case Control|
|Official Title:||Hypothalamo-, Pituitary-, Adrenal Axis Dysfunction in Subarachnoid Hemorrhage|
|Study Start Date :||March 2006|
|Actual Primary Completion Date :||November 2006|
|Actual Study Completion Date :||January 2008|
Patients scheduled for elective cerebral aneurysmal surgery
Patients with subarachnoid hemorrhage
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00614887
|Department of Intensive Care, Kuopio University Hospital|
|Kuopio, Pl 1777, Finland, 70211|
|Principal Investigator:||Stepani J Bendel, MD||Department of Intensive Care, Kuopio University Hospital, FINLAND|
|Study Director:||Ari Uusaro, MD, Phd||Department of Intensive Care, Kuopio University Hospital, FINLAND|
|Study Director:||Timo Koivisto, MD, Phd||Department of Neurosurgery, Kuopio Universtiy Hospital, FINLAND|