The Effects of a Prostaglandin Inhibitor on Ovulation and the Menstrual Cycle
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00614406
: February 13, 2008
Results First Posted
: July 4, 2012
Last Update Posted
: December 13, 2012
Oregon Health and Science University
Society of Family Planning
Information provided by (Responsible Party):
Alison Edelman, Oregon Health and Science University
Currently available methods of emergency contraception (EC) only work during a very narrow time period prior to the hormonal trigger for ovulation or the release of an egg. Women having unprotected sex outside this window receive no benefits from this emergency therapy. Prostaglandins are critical before, during, and after ovulation, thus their inhibition may cause an EC effect that works over a longer time period. We wanted to determine if celecoxib might work as an EC with a wider window of action.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study:
18 Years to 35 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Normal menstrual periods (24-35 days)
Good general health
Willing to use a non-hormonal form of contraception for the entire study (Acceptable forms of contraception include condoms, spermicide, sexual contact with a sterilized partner, subject is surgically sterile, same-sex partner, Copper IUD and abstinence)
Willing and able to return to clinic for bi-weekly blood tests
Pregnant or breast feeding
Polycystic ovarian disease
Gastrointestinal conditions (i.e.gastric ulcer)
Currently using birth control
Known allergy to aspirin, non-steroidal anti-inflammatory drugs (NSAIDS) or Sulfa-drugs