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Organization in Acute Atrial Fibrillation Post Open Heart Surgery (A-Fib)

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ClinicalTrials.gov Identifier: NCT00614107
Recruitment Status : Unknown
Verified January 2008 by State University of New York - Upstate Medical University.
Recruitment status was:  Enrolling by invitation
First Posted : February 13, 2008
Last Update Posted : February 13, 2008
Sponsor:
Information provided by:

Study Description
Brief Summary:

A form of irregular heart rate called, Atrial Fibrillation (AF) is a major clinical problem. It afflicts about 2 million Americans and is the single largest heart related cause of stroke. However, despite 120 years of speculation and research, the mechanisms that cause AF are poorly understood. Acute AF is also the most common irregular heart rate after open-heart surgery in patients. This is seen in as many as 30% of such patients and often results in a longer hospital stay.

In this study we would like to study the pattern of atrial fibrosis (scar tissue in the heart) and an associated blood marker (a protein called pro-collagen-1) in those patients concurrently having open heart surgery.


Condition or disease
Atrial Fibrillation

Study Design

Study Type : Observational
Actual Enrollment : 75 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Organization in Acute Atrial Fibrillation Post Open Heart Surgery
Study Start Date : January 2008
Estimated Primary Completion Date : January 2009
Estimated Study Completion Date : January 2009

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Groups and Cohorts


Outcome Measures

Biospecimen Retention:   Samples With DNA
Tissue sample for the right and left sid eof the heart.

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 79 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Any person over 18 years having an elective valve, CABG or combination procedure
Criteria

Inclusion Criteria:

  1. 18 years of age, Male or Female
  2. Able to provide consent
  3. Cardiac surgery, CABG of Valve replacement or repair.

Exclusion Criteria:

  1. If AF terminates within 1 hour of initiation.
  2. If the patient undergoes electrical cardioversion and/or receives digitalis within the first hour of inclusion.
  3. If the patients and/or their family or the primary caregiver choose to be excluded from the study anytime, even after the initial 24-hour period.
  4. If the patient expires within 1 hour of inclusion into the study. -
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00614107


Locations
United States, New York
SUNY Upstate Medical University
Syracuse, New York, United States, 13210
Sponsors and Collaborators
State University of New York - Upstate Medical University
More Information

Responsible Party: Gregory Fink, SUNY Upstate Medical UNiversity
ClinicalTrials.gov Identifier: NCT00614107     History of Changes
Other Study ID Numbers: 5301UMU
First Posted: February 13, 2008    Key Record Dates
Last Update Posted: February 13, 2008
Last Verified: January 2008

Keywords provided by State University of New York - Upstate Medical University:
Atrial Fibrillation post open heart surgery

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes