Advanced MRI in Major Depression

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00613912
Recruitment Status : Completed
First Posted : February 13, 2008
Last Update Posted : November 21, 2011
Information provided by (Responsible Party):
University of Aarhus

Brief Summary:

Depression is the most common psychiatric disorder.

  • 3-5% of a given population has major depression.
  • Less than 50% of the depressed in Denmark are diagnosed with major depression.
  • 25-50% of the depressed have a relative with major depression-underlying brain pathology?

The purpose of this study is to use MRI to evaluate cerebral morphology and function in ambulant patients with major depression

Condition or disease Intervention/treatment
Depressive Disorder, Major Other: Magnetic Resonance Imaging

Detailed Description:

Previous studies within major depression, have often included hospitalized patients with severe symptoms and imaging have been performed with PET and SPECT, which uses ionizing radiation. This study focus on ambulant patients(with or without medication/ECT treatment), to find patients in an earlier stage. Cerebral perfusion with the MR sequence Arterial Spin Labelling, concentrations of different metabolites with MR spectroscopy and brain volumetry with BRAVO 3D T1 ax will be performed.

MR protocol: T2 sag, T2 FLAIR ax, ASL ax, MRS and 3D T1 ax. Scan time 45 min.

Study Type : Observational
Actual Enrollment : 49 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Advanced MRI at 3T for the Evaluation of Ambulant Patients With Major Depression
Study Start Date : March 2008
Actual Primary Completion Date : December 2009
Actual Study Completion Date : June 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: MRI Scans

Group/Cohort Intervention/treatment
Ambulant patients with major depression
Other: Magnetic Resonance Imaging
  • Morphological sequences
  • Arterial Spin Labelling (Perfusion)
  • Spectroscopy: anterior cingulate cortex Naa, Cho, Cr, Myo-inositol, glutamate TE 30 Reference voxel in Parietal white matter
Other Name: 3 Tesla GE Scanner HDx

Primary Outcome Measures :
  1. Differences in morphological and functional cerebral MRI findings in patients suffering from major depression [ Time Frame: 6 months from first MRI in each patient ]

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Ambulant patients with major depression, selected from the Department of Psychatry, Aalborg hospital-Århus University Hospital.

Inclusion Criteria:

  • Patients who fulfil ICD-10´s criteria for major depression, found within the ambulant psychiatric sector and who has a HAM-D ≥ 18

Exclusion Criteria:

  • If the patient has pacemaker or other magnetic devices
  • Pregnancy
  • Has had an operation in the brain
  • bipolar disorder

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00613912

Aalborg Hospital / Aarhus University Hospital
Aalborg, Jutland, Denmark, 9000
Sponsors and Collaborators
University of Aarhus
Principal Investigator: Elna-Marie B Larsson, Professor Uppsala University Hospital

Responsible Party: University of Aarhus Identifier: NCT00613912     History of Changes
Other Study ID Numbers: AUFF-2005-740-004
First Posted: February 13, 2008    Key Record Dates
Last Update Posted: November 21, 2011
Last Verified: November 2011

Keywords provided by University of Aarhus:
Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Perfusion, brain

Additional relevant MeSH terms:
Depressive Disorder
Depressive Disorder, Major
Behavioral Symptoms
Mood Disorders
Mental Disorders