The Role of Tea Catechins and Caffeine in Relation to Energy Metabolism
This study has been completed.
Sponsor:
University of Copenhagen
Collaborator:
Unilever R&D
Information provided by:
University of Copenhagen
ClinicalTrials.gov Identifier:
NCT00611416
First received: August 21, 2007
Last updated: February 6, 2009
Last verified: February 2009
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Purpose
The aim of this study is to elucidate the role of specific catechins, a mixture of catechins and caffeine in relation to weight control with particular emphasis on energy metabolism and fat oxidation.
| Condition | Intervention |
|---|---|
|
Obesity |
Dietary Supplement: green tea Dietary Supplement: Mix of catechins and caffeine Dietary Supplement: EGCG Dietary Supplement: EGC Dietary Supplement: Caffeine Dietary Supplement: Placebo |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Crossover Assignment Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor) Primary Purpose: Treatment |
| Official Title: | The Role of Tea Catechins and Caffeine in Relation to Energy Metabolism in Man |
Resource links provided by NLM:
Further study details as provided by University of Copenhagen:
Primary Outcome Measures:
- fat oxidation [ Time Frame: november 2007 ]
Secondary Outcome Measures:
- appetite [ Time Frame: november 2007 ]
| Enrollment: | 15 |
| Study Start Date: | November 2005 |
| Study Completion Date: | February 2006 |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: 1
Active treatment A
|
Dietary Supplement: green tea
different catechin combinations
Dietary Supplement: Mix of catechins and caffeine
3 tablet a day
|
|
Experimental: 2
Active treatment B
|
Dietary Supplement: green tea
different catechin combinations
Dietary Supplement: EGCG
3 tablets a day
Other Name: epigallocatechin gallate
|
|
Experimental: 3
Active treatment C
|
Dietary Supplement: green tea
different catechin combinations
Dietary Supplement: EGC
3 tablets a day
Other Name: Epigallocatechin
|
|
Active Comparator: 4
Positive control
|
Dietary Supplement: Caffeine
3 tablets a day
|
|
Placebo Comparator: 5
Placebo
|
Dietary Supplement: Placebo
3 tablets a day
|
Show Detailed Description
Eligibility| Ages Eligible for Study: | 18 Years to 40 Years (Adult) |
| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria:
- Healthy men
- Age 18-40 years
- BMI 18,5-25 kg/m2
Exclusion Criteria:
- Diabetes or any other endocrinological disease
- Hypertensive medication
- Increased Blood Pressure > 140/85
- Hyperlpidimia
- Chronic disease (i.e. HIV)
- Use of any diet supplements including vitamins (during and 3 months prior to the study).
- High alcohol intake (>21 units a week)
- High caffeine intake (>250 mg/day) or high catechin intake (>200 mg/day)
- Smoking
- Elite sports performer
- Use of any regular medication
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00611416
Please refer to this study by its ClinicalTrials.gov identifier: NCT00611416
Locations
| Denmark | |
| Institute of Human Nutrition, The Royal Veterinary and Agricultrual University | |
| Frederiksberg C, Denmark, 1958 | |
Sponsors and Collaborators
University of Copenhagen
Unilever R&D
Investigators
| Study Chair: | Arne Astrup, Proffessor | Insitute of Human Nutrition |
More Information
| ClinicalTrials.gov Identifier: | NCT00611416 History of Changes |
| Other Study ID Numbers: | (KF) 01 279421 Unilever |
| Study First Received: | August 21, 2007 |
| Last Updated: | February 6, 2009 |
| Health Authority: | Denmark: The Danish National Committee on Biomedical Research Ethics |
Keywords provided by University of Copenhagen:
|
catechins caffeine energy expenditure fat oxidation appetite |
Additional relevant MeSH terms:
|
Caffeine Epigallocatechin gallate Central Nervous System Stimulants Physiological Effects of Drugs Phosphodiesterase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Purinergic P1 Receptor Antagonists Purinergic Antagonists |
Purinergic Agents Neurotransmitter Agents Antioxidants Protective Agents Antimutagenic Agents Anticarcinogenic Agents Antineoplastic Agents Neuroprotective Agents |
ClinicalTrials.gov processed this record on September 26, 2016