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Effects of Delivery Mode of Cognition Intervention in Early Alzheimer's Disease

This study has been completed.
Alzheimer's Association
Information provided by (Responsible Party):
Yvonne Colgrove, PT, PhD, University of Kansas Identifier:
First received: January 28, 2008
Last updated: October 2, 2012
Last verified: October 2012
The purpose of this study is to see if an intense two-week long cognitive training program helps the thinking ability of adults with very mild Alzheimer Disease. We anticipate that scores on clinical cognitive tests will be better after the training.

Condition Intervention Phase
Alzheimer's Disease Behavioral: Cognitive Training Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Supportive Care
Official Title: Effects of Intense Cognitive Training on Standardized Measures of Cognition in Those With Very Mild Alzheimer's Disease

Resource links provided by NLM:

Further study details as provided by Yvonne Colgrove, PT, PhD, University of Kansas:

Primary Outcome Measures:
  • Composite score of 5 cognitive tests including 1)WAIS digit span, 2) word fluency, 3) trail making test-A 4) Rey Osterrieth complex figure and 5) MMSE [ Time Frame: 2 weeks with FU at 2 and 4 months ]

Secondary Outcome Measures:
  • Brain activity during functional brain imaging [ Time Frame: 2 weeks ]

Enrollment: 25
Study Start Date: February 2008
Study Completion Date: September 2012
Primary Completion Date: May 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Cognitive Training
Behavioral: Cognitive Training
Intense cognitive training, two consecutive weeks, each weekday, 6 hours/day

Detailed Description:
Twenty of the 30 subjects will be recruited to participate in functional magnetic resonance imaging (fMRI). Scanning will be done while subjects perform a verbal learning task. Ten subjects will be scanned before and after the two week training. Another ten will be scanned twice at a two week interval before beginning the cognitive training.

Ages Eligible for Study:   60 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Diagnosis of very mild Alzheimer's Disease (CDC of 0.5) and mild Alzheimer's Disease (CDC of 1.0)

Exclusion Criteria:

  • Neurologic disorder other than Alzheimer's disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT00611312

United States, Kansas
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Sponsors and Collaborators
University of Kansas
Alzheimer's Association
Principal Investigator: Yvonne Colgrove, PhD, PT University of Kansas Medical Center
  More Information

Responsible Party: Yvonne Colgrove, PT, PhD, Principal Investigator, University of Kansas Identifier: NCT00611312     History of Changes
Other Study ID Numbers: IIRG-07-57789
Study First Received: January 28, 2008
Last Updated: October 2, 2012

Keywords provided by Yvonne Colgrove, PT, PhD, University of Kansas:
Alzheimer's disease
Cognitive training

Additional relevant MeSH terms:
Alzheimer Disease
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Neurocognitive Disorders
Mental Disorders processed this record on August 18, 2017