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Examination of the Effects of Four Different Spices on Energy Metabolism

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00611156
Recruitment Status : Completed
First Posted : February 8, 2008
Last Update Posted : February 8, 2008
University of Aarhus
Information provided by:
University of Copenhagen

Brief Summary:

The objective of this study is to examine whether four different spices (ginger, black pepper, horseradish and mustard) are able to increase energy metabolism.

Since chili and other spices have been shown to increase energy expenditure compared to placebo, we expect that some or all of the four spices may actually increase energy expenditure - although not to a large degree.

Condition or disease Intervention/treatment Phase
Healthy Dietary Supplement: ginger Dietary Supplement: black pepper Dietary Supplement: horseradish Dietary Supplement: mustard Dietary Supplement: placebo Not Applicable

Detailed Description:
Several pungent food ingredients, such as chili,and also other bioactive food ingredients, e.g. green tea, have been shown to be able to increase energy expenditure and fat oxidation during the hours following a meal containing the bioactive ingredient. Furthermore, we will also look at the subjects own feelings of appetite and thereby examine whether the appetite is affected by the spicy food. We expect to see some small effects on these parameters.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 22 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Investigator)
Primary Purpose: Prevention
Official Title: Bioactive Food Ingredients and Energy Metabolism: The Effects of Ginger, Black Pepper, Horseradish and Mustard on Meal-Induced Thermogenesis and Fat Oxidation
Study Start Date : October 2006
Actual Study Completion Date : June 2007

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: A
Dietary Supplement: ginger
added to a brunch meal

Experimental: B
Dietary Supplement: black pepper
Added to a brunch meal

Experimental: C
Dietary Supplement: horseradish
Added to a brunch meal

Experimental: D
Dietary Supplement: mustard
Added to a brunch meal

Placebo Comparator: E
Dietary Supplement: placebo
Added to a bruch meal

Primary Outcome Measures :
  1. energy expenditure [ Time Frame: November 2007 ]

Secondary Outcome Measures :
  1. blood pressure [ Time Frame: December 2007 ]
  2. heart rate [ Time Frame: December 2007 ]
  3. VAS-scores for appetite, hunger, fullness, etc. - and palatability [ Time Frame: November 2007 ]
  4. tolerance [ Time Frame: November 2007 ]
  5. Fat and carbohydrate oxidation [ Time Frame: November 2007 ]
  6. Meal-induced thermogenesis [ Time Frame: November 2007 ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • male
  • healthy and not use medication (regularly)
  • normal weight
  • non smoker
  • tolerate and like spicy food
  • stable body weight last two months

Exclusion Criteria:

  • increased blood pressure
  • abnormal EKG
  • mental, metabolic and chronic diseases

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00611156

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Department of Human Nutrition, The Royal Veterinary and Agricultural University
Frederiksberg, Denmark, DK-1958
Sponsors and Collaborators
University of Copenhagen
University of Aarhus
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Study Chair: Arne Astrup, Professor MD Department of Human Nutrition, RVAU

Publications automatically indexed to this study by Identifier (NCT Number):
Layout table for additonal information Identifier: NCT00611156     History of Changes
Other Study ID Numbers: B228-IHE-2006-NTG
First Posted: February 8, 2008    Key Record Dates
Last Update Posted: February 8, 2008
Last Verified: August 2007

Keywords provided by University of Copenhagen:
Meal-induced thermogenesis
energy expenditure
fat oxidation
bioactive ingredients
black pepper

Additional relevant MeSH terms:
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Alkylating Agents
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents, Alkylating
Antineoplastic Agents