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Trial record 20 of 126 for:    "Viral Infectious Disease" | "Ethanol"

Study of T Cell Phenotype Activation Pathway in Human Alcoholic Liver Disease

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00610597
Recruitment Status : Completed
First Posted : February 8, 2008
Last Update Posted : February 8, 2008
Information provided by:
Erasme University Hospital

Brief Summary:
Alcoholic liver disease is characterized by circulating T cell activation and liver T cell infiltration but their phenotype is poorly studied. The aim of the study is to test the hypothesis that the (CD4+ T cell secreting Interleukin-17) Th17 pathway is involved in alcoholic liver disease.

Condition or disease
Alcoholic Liver Disease Chronic Hepatitis C Virus

Detailed Description:
Consecutive patients undergoing transjugular liver biopsies for alcoholic liver disease or hepatitis C virus infection will be included in the study to measure plasma cytokines levels, peripheral blood mononuclear cells cytokine release and liver T cell infiltrates.

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Study Type : Observational
Actual Enrollment : 49 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Study of T Cell Phenotype Activation Pathway in Human Alcoholic Liver Disease
Study Start Date : January 2005
Actual Primary Completion Date : January 2007
Actual Study Completion Date : January 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Liver Diseases

alcoholic liver disease
chronic hepatitis C virus infection

Biospecimen Retention:   Samples Without DNA
plasma and peripheral blood mononuclear cell culture medium.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
patients of Erasme University Hospital

Inclusion Criteria:

  • Alcohol excess intake and suspected liver disease
  • Alcohol excess intake and clinical liver cirrhosis
  • chronic hepatitis C virus infection and suspected liver disease
  • chronic hepatitis C virus infection and clinical liver cirrhosis

Exclusion Criteria:

  • bacterial or fungal infection
  • immunosuppressive treatment
  • other causes of liver disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00610597

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Hopital Erasme - Dpt of Gastroenterology
Brussels, Belgium
Sponsors and Collaborators
Erasme University Hospital
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Principal Investigator: Arnaud Lemmers, MD Erasme Hospital, Gastroenterology Dpt

Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Olivier Le Moine, MD, PhD, Erasme University Hospital Identifier: NCT00610597     History of Changes
Other Study ID Numbers: AL-ALD
First Posted: February 8, 2008    Key Record Dates
Last Update Posted: February 8, 2008
Last Verified: January 2008
Keywords provided by Erasme University Hospital:
Additional relevant MeSH terms:
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Virus Diseases
RNA Virus Infections
Hepatitis C
Hepatitis C, Chronic
Liver Diseases
Liver Diseases, Alcoholic
Digestive System Diseases
Hepatitis, Viral, Human
Flaviviridae Infections
Hepatitis, Chronic
Alcohol-Induced Disorders
Alcohol-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders