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Study of T Cell Phenotype Activation Pathway in Human Alcoholic Liver Disease

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00610597
First Posted: February 8, 2008
Last Update Posted: February 8, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Erasme University Hospital
  Purpose
Alcoholic liver disease is characterized by circulating T cell activation and liver T cell infiltration but their phenotype is poorly studied. The aim of the study is to test the hypothesis that the (CD4+ T cell secreting Interleukin-17) Th17 pathway is involved in alcoholic liver disease.

Condition
Alcoholic Liver Disease Chronic Hepatitis C Virus

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Study of T Cell Phenotype Activation Pathway in Human Alcoholic Liver Disease

Resource links provided by NLM:


Further study details as provided by Erasme University Hospital:

Biospecimen Retention:   Samples Without DNA
plasma and peripheral blood mononuclear cell culture medium.

Enrollment: 49
Study Start Date: January 2005
Study Completion Date: January 2008
Primary Completion Date: January 2007 (Final data collection date for primary outcome measure)
Groups/Cohorts
1
alcoholic liver disease
2
chronic hepatitis C virus infection

Detailed Description:
Consecutive patients undergoing transjugular liver biopsies for alcoholic liver disease or hepatitis C virus infection will be included in the study to measure plasma cytokines levels, peripheral blood mononuclear cells cytokine release and liver T cell infiltrates.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
patients of Erasme University Hospital
Criteria

Inclusion Criteria:

  • Alcohol excess intake and suspected liver disease
  • Alcohol excess intake and clinical liver cirrhosis
  • chronic hepatitis C virus infection and suspected liver disease
  • chronic hepatitis C virus infection and clinical liver cirrhosis

Exclusion Criteria:

  • bacterial or fungal infection
  • immunosuppressive treatment
  • other causes of liver disease
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00610597


Locations
Belgium
Hopital Erasme - Dpt of Gastroenterology
Brussels, Belgium
Sponsors and Collaborators
Erasme University Hospital
Investigators
Principal Investigator: Arnaud Lemmers, MD Erasme Hospital, Gastroenterology Dpt
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Olivier Le Moine, MD, PhD, Erasme University Hospital
ClinicalTrials.gov Identifier: NCT00610597     History of Changes
Other Study ID Numbers: AL-ALD
First Submitted: January 28, 2008
First Posted: February 8, 2008
Last Update Posted: February 8, 2008
Last Verified: January 2008

Keywords provided by Erasme University Hospital:
liver
alcohol
lymphocyte

Additional relevant MeSH terms:
Hepatitis C
Hepatitis, Chronic
Hepatitis C, Chronic
Liver Diseases
Liver Diseases, Alcoholic
Hepatitis, Viral, Human
Virus Diseases
Flaviviridae Infections
RNA Virus Infections
Hepatitis
Digestive System Diseases
Alcohol-Induced Disorders
Alcohol-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders