Treatment of Acute Pharyngo-Tonsillitis With Essential Oils of Aromatic Plants
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ClinicalTrials.gov Identifier: NCT00610519 |
Recruitment Status
:
Completed
First Posted
: February 8, 2008
Last Update Posted
: June 17, 2008
|
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This randomized, double blind, parallel group study, compared the efficacy of spray containing aromatic essential oils of some herbal plants, against placebo in the treatment of patients with acute viral Pharyngo-tonsillitis.
Study objectives: Primary to demonstrate a throat pain relief within 20 minutes after first administration of treatment with the spray.
Secondary to demonstrate a reduction of a defined symptoms sum score based on symptoms and signs comparing baseline therapy from the beginning to the end of 3 days treatment
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Viral Pharyngitis Viral Tonsillitis | Dietary Supplement: mixture of aromatic essential oils. Dietary Supplement: placebo | Phase 1 Phase 2 |
This study compared the efficacy of spray containing aromatic essential oils of Eucalyptus citriodora, Eucalyptus globulus, Mentha piperita, Origanum syriacum, and Rosmarinus Officinalis, against placebo in the treatment of patients with acute viral Pharyngo-tonsillitis.
In- vitro and clinical studies suggest therapeutic potential of aromatic herbs and trees oils in the treatment of Pharyngo-Tonsillitis. The pharmacological and clinical activity of Eucalyptus citriodora, Eucalyptus globulus, Mentha piperita, Origanum syriacum, and Rosmarinus Officinalis, include anti-inflammatory, anti-bacterial and anti-viral activities. Some of these herbs and trees oils have direct activity on the respiratory tract, the coughing reflex and the airflow in the nasal tract.
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 33 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double (Participant, Investigator) |
Primary Purpose: | Treatment |
Official Title: | Treatment of Acute Pharyngo-Tonsillitis With Essential Oils of Some Aromatic Medical Plants. |
Study Start Date : | January 2008 |
Actual Primary Completion Date : | May 2008 |
Actual Study Completion Date : | May 2008 |

Arm | Intervention/treatment |
---|---|
Active Comparator: 1
treatment with spray containing aromatic essential oils of some herbal plants.
|
Dietary Supplement: mixture of aromatic essential oils.
3% of mixture containing aromatic essential oils of Eucalyptus citriodora, Eucalyptus globulus, Mentha piperita, Origanum syriacum, and Rosmarinus Officinalis, spraying to the throat.
|
Placebo Comparator: 2
spray containing placebo.
|
Dietary Supplement: placebo
0:1% of Lemon VIP (Florasynth,Israel), spraying to the throat.
|
- To demonstrate a throat pain relief within the first 20 minutes after first administration of treatment with the spray. [ Time Frame: 20 minutes ]
- To demonstrate a reduction of a defined symptoms sum score based on symptoms and signs comparing baseline therapy from the beginning to the end of 3 days treatment. [ Time Frame: 3 days ]

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Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Clinical diagnosis of acute viral pharyngo-tonsillitis.
- Active disease less than 48 hours
- Patients agree to sign informed consent according to GCP and Israel national regulations.
Exclusion Criteria:
- Acute follicular tonsillitis.
- Peritonsillar abscess.
- Under any antibiotically treatment.
- Asthma disease.
- Under coumadine therapy.
- Hyper sensitivity to Aromatic essential oils.
- Any immuno-suppressive disease

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00610519
Israel | |
Otorhinolaryngology department | |
Afula, Israel, 18101 |
Principal Investigator: | Yoseph Rakover, M.D. | haemek medical center |
Responsible Party: | Yoseph Rakover, M.D., Head of Department of Otorhinolaryngology, HaEmek Medical Center, Israel |
ClinicalTrials.gov Identifier: | NCT00610519 History of Changes |
Other Study ID Numbers: |
emc070167ctil Rakover1 |
First Posted: | February 8, 2008 Key Record Dates |
Last Update Posted: | June 17, 2008 |
Last Verified: | June 2008 |
Keywords provided by HaEmek Medical Center, Israel:
Viral pharyngo-tonsillitis; Herbal medicine; Traditional medicine; Aromatic essential oils; |
Additional relevant MeSH terms:
Pharyngitis Tonsillitis Pharyngeal Diseases Stomatognathic Diseases |
Respiratory Tract Infections Respiratory Tract Diseases Otorhinolaryngologic Diseases |