Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS)

This study has been completed.

Sponsor:

Collaborator:

Mainz University

Information provided by (Responsible Party):

Beckman Laser Institute and Medical Center, University of California, Irvine

ClinicalTrials.gov Identifier:

NCT00610402

First received: January 25, 2008

Last updated: August 5, 2015

Last verified: August 2015

History of Changes

Purpose

Sturge-Weber Syndrome (SWS) is a neurological disorder characterized at birth by seizures and a large port-wine stain birthmark on the forehead and upper eyelid of one side of the face. SWS is also accompanied by an increased pressure within the eye (glaucoma) which can develop very early in life.

Glaucoma represents a group of ocular disorders that are characterized by the loss of retinal ganglion cells and their axons, damage to the optic nerve, and gradual loss of visual field. Recently, several studies provided evidence that there is a potential role of the immune system in the pathogenesis of glaucoma.

These findings suggest that there might be changes in systemic humoral immunity possibly underlying the optic neuropathy in at least some glaucoma patients.

Condition	Intervention
Sturge - Weber Syndrome (SWS)	Other: blood sample tear drop sample


Study Type:	Observational
Study Design:	Observational Model: Case-Only Time Perspective: Prospective
Official Title:	Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS)

Resource links provided by NLM:

Genetics Home Reference related topics: Klippel-Trenaunay syndrome Parkes Weber syndrome

MedlinePlus related topics: Tears

Genetic and Rare Diseases Information Center resources: Klippel-Trenaunay Syndrome Parkes Weber Syndrome Weber Syndrome Sturge-Weber Syndrome

U.S. FDA Resources

Further study details as provided by University of California, Irvine:

Biospecimen Retention: Samples Without DNA

blood sample tear drop sample


Enrollment:	57
Study Start Date:	July 2007
Study Completion Date:	June 2008
Primary Completion Date:	July 2007 (Final data collection date for primary outcome measure)

Groups/Cohorts	Assigned Interventions
blood sample tear drop sample blood sample tear drop sample	Other: blood sample tear drop sample blood sample tear drop sample

Detailed Description:

The ocular antibody profile in patients with SWS is unknown.The researchers want to study on blood and tear drop samples from patients with SWS to determine the incidence of ocular antibodies in patients with this syndrome.

Eligibility


Ages Eligible for Study:	Child, Adult, Senior
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

community sample

Criteria

Inclusion Criteria:

Male and female volunteers with SWS of all ages

Exclusion Criteria:

Volunteers without SWS

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00610402

Locations


United States, California
Beckman Laser Institute Medical clinic
Irvine, California, United States, 92612

Sponsors and Collaborators

University of California, Irvine

Mainz University

Investigators


Principal Investigator:	John S Nelson, M.D,PhD	Beckman Laser Institute University of California Irvine

More Information


Responsible Party:	Beckman Laser Institute and Medical Center, J.S.Nelson, MD,PhD,Professor of Surgery and Biomedical Engineering, University of California, Irvine
ClinicalTrials.gov Identifier:	NCT00610402 History of Changes
Other Study ID Numbers:	NIH-LAMMP-2006-5691
Study First Received:	January 25, 2008
Last Updated:	August 5, 2015
Health Authority:	United States: Institutional Review Board

Additional relevant MeSH terms:


Syndrome Brain Stem Infarctions Klippel-Trenaunay-Weber Syndrome Sturge-Weber Syndrome Disease Pathologic Processes Brain Infarction Brain Ischemia Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases	Stroke Vascular Diseases Cardiovascular Diseases Angiomatosis Hemangioma Neoplasms, Vascular Tissue Neoplasms by Histologic Type Neoplasms Neurocutaneous Syndromes Antibodies Immunologic Factors Physiological Effects of Drugs

ClinicalTrials.gov processed this record on September 23, 2016

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