Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS)
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT00610402 |
Recruitment Status :
Completed
First Posted : February 8, 2008
Last Update Posted : February 10, 2017
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Sturge-Weber Syndrome (SWS) is a neurological disorder characterized at birth by seizures and a large port-wine stain birthmark on the forehead and upper eyelid of one side of the face. SWS is also accompanied by an increased pressure within the eye (glaucoma) which can develop very early in life.
Glaucoma represents a group of ocular disorders that are characterized by the loss of retinal ganglion cells and their axons, damage to the optic nerve, and gradual loss of visual field. Recently, several studies provided evidence that there is a potential role of the immune system in the pathogenesis of glaucoma.
These findings suggest that there might be changes in systemic humoral immunity possibly underlying the optic neuropathy in at least some glaucoma patients.
Condition or disease | Intervention/treatment |
---|---|
Sturge - Weber Syndrome (SWS) | Other: blood sample tear drop sample |
Study Type : | Observational |
Actual Enrollment : | 57 participants |
Observational Model: | Case-Only |
Time Perspective: | Prospective |
Official Title: | Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS) |
Study Start Date : | July 2007 |
Actual Primary Completion Date : | July 2007 |
Actual Study Completion Date : | June 2008 |

Group/Cohort | Intervention/treatment |
---|---|
blood sample tear drop sample
blood sample tear drop sample
|
Other: blood sample tear drop sample
blood sample tear drop sample |

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Ages Eligible for Study: | Child, Adult, Older Adult |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Male and female volunteers with SWS of all ages
Exclusion Criteria:
- Volunteers without SWS

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00610402
United States, California | |
Beckman Laser Institute Medical clinic | |
Irvine, California, United States, 92612 |
Principal Investigator: | John S Nelson, M.D,PhD | Beckman Laser Institute University of California Irvine |
Responsible Party: | Beckman Laser Institute and Medical Center, J.S.Nelson, MD,PhD,Professor of Surgery and Biomedical Engineering, University of California, Irvine |
ClinicalTrials.gov Identifier: | NCT00610402 History of Changes |
Other Study ID Numbers: |
NIH-LAMMP-2006-5691 |
First Posted: | February 8, 2008 Key Record Dates |
Last Update Posted: | February 10, 2017 |
Last Verified: | February 2017 |
Sturge-Weber Syndrome Brain Stem Infarctions Klippel-Trenaunay-Weber Syndrome Syndrome Disease Pathologic Processes Brain Infarction Brain Ischemia Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases Nervous System Diseases |
Stroke Vascular Diseases Cardiovascular Diseases Angiomatosis Hemangioma Neoplasms, Vascular Tissue Neoplasms by Histologic Type Neoplasms Neurocutaneous Syndromes Antibodies Immunologic Factors Physiological Effects of Drugs |