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Balanced Volume Replacement Therapy With Ringer's Acetate Solution in Burn Injury (VoLTRAB)

This study has been completed.
Information provided by (Responsible Party):
Armin Sablotzki, MD, Klinikum St. Georg gGmbH Identifier:
First received: January 25, 2008
Last updated: October 14, 2011
Last verified: October 2011
This observational study compares the influence of Ringer's Lactate solution and Ringer's Acetate solution on organ function scores following severe burn injury.

Severe Burn Injury

Study Type: Observational
Study Design: Observational Model: Cohort
Official Title: Balanced Volume Replacement Therapy With Ringer's Acetate Solution in Burn Injury

Resource links provided by NLM:

Further study details as provided by Klinikum St. Georg gGmbH:

Primary Outcome Measures:
  • Change of SOFA-score from day 3 to day 7 after severe burn injury [ Time Frame: day3, day7, day28, day60 ]

Secondary Outcome Measures:
  • Changes in electrolyte-balance [ Time Frame: day3, day7, day28 ]

Enrollment: 82
Study Start Date: December 2007
Study Completion Date: December 2010
Primary Completion Date: November 2010 (Final data collection date for primary outcome measure)
Historical group: patients treated with Ringer's Lactate solution after severe burn injury
Actual group: patients treated with Ringer's Acetate solution after severe burn injury

Detailed Description:
In the early period following severe burn injury volume replacement with high amounts of crystalloids is necessary. In this study we compare the organ function scores of a historical patient group, treated with Ringer's Lactate solution, with an actual patient population, treated with Ringer's Acetate solution.

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
patients within a 24-hours period after severe burn injury

Inclusion Criteria:

  • Age >=18 years and <80years
  • Burned surface area >20% and <70%
  • Burn injury < 24 hours
  • Agreement to the study procedures

Exclusion Criteria:

  • Burned surface area > 70%
  • Expected survival time < 24 hours
  • Acute or chronic heart failure NYHA III or IV
  • Adult respiratory distress syndrome
  • Renal failure
  • Hepatic failure
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Please refer to this study by its identifier: NCT00609700

Klinikum St Georg
Leipzig, Sachsen, Germany, 04129
Sponsors and Collaborators
Klinikum St. Georg gGmbH
Principal Investigator: Armin R Sablotzki, MD Klinikum St. Georg Leipzig
  More Information

Additional Information:
Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Armin Sablotzki, MD, prof. Dr. med., Klinikum St. Georg gGmbH Identifier: NCT00609700     History of Changes
Other Study ID Numbers: EK-BR-35/07-1
Study First Received: January 25, 2008
Last Updated: October 14, 2011

Keywords provided by Klinikum St. Georg gGmbH:
burn injury
volume replacement
Ringer's Lactate solution
Ringer's Acetate solution
volume replacement with crystalloids

Additional relevant MeSH terms:
Wounds and Injuries
Pharmaceutical Solutions processed this record on April 28, 2017