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Association Between Cytokines and Severity of Respiratory Syncytial Virus (RSV)-Induced Illness in the Elderly

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ClinicalTrials.gov Identifier: NCT00609635
Recruitment Status : Completed
First Posted : February 7, 2008
Last Update Posted : April 6, 2009
American Academy of Allergy, Asthma, and Immunology
Information provided by:
West Penn Allegheny Health System

Brief Summary:

This research study involves studying the genes that may affect how ill you become during respiratory infection with respiratory syncytial virus (RSV). RSV is a virus that often causes common colds.

Cytokines are chemicals that are naturally made by your body. Cytokine levels are increased in some people when they have common colds or wheezing caused by respiratory syncytial virus (RSV). The purpose of this study is to study the genes that may control cytokine levels during infection with RSV in the elderly population.

Condition or disease
Respiratory Syncytial Virus Infections

Study Type : Observational
Estimated Enrollment : 300 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Association Between Cytokine Genotype Polymorphisms and Severity of RSV-Induced Illness in the Elderly
Study Start Date : November 2007
Primary Completion Date : April 2009
Study Completion Date : April 2009

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Biospecimen Retention:   Samples With DNA
A buccal brushing (cells collected from the inside of the cheek) will be collected and stored for DNA analysis.

Information from the National Library of Medicine

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Ages Eligible for Study:   65 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
inpatient or outpatient subjects with respiratory illnesses potentially caused by RSV

Inclusion Criteria:

  • Subjects > 65 years of age diagnosed with RSV-induced respiratory illness
  • Diagnosis (based upon ICD-9-CM codes) for pneumonia, upper respiratory illness, bronchitis, COPD, asthma, viral illness, or congestive heart failure (CHF)
  • Willing to sign informed consent.

Exclusion Criteria:

  • Not willing to sign informed consent.
  • Subjects less that 65 years of age
  • Subjects not diagnosed with a respiratory illness

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00609635

United States, Pennsylvania
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States, 15212
Sponsors and Collaborators
West Penn Allegheny Health System
American Academy of Allergy, Asthma, and Immunology
Principal Investigator: Ritu Pabby, MD West Penn Allegheny Health System

Responsible Party: Ritu Pabby, MD, Allegheny General Hosptial Dept. of Allergy, Asthma, & Immunology
ClinicalTrials.gov Identifier: NCT00609635     History of Changes
Other Study ID Numbers: Adult RSV RC# 4212
First Posted: February 7, 2008    Key Record Dates
Last Update Posted: April 6, 2009
Last Verified: April 2009

Keywords provided by West Penn Allegheny Health System:
RSV-induced respiratory illness

Additional relevant MeSH terms:
Virus Diseases
Respiratory Syncytial Virus Infections
Pneumovirus Infections
Paramyxoviridae Infections
Mononegavirales Infections
RNA Virus Infections