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Association Between Cytokines and Severity of Respiratory Syncytial Virus (RSV)-Induced Illness in the Elderly

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00609635
First Posted: February 7, 2008
Last Update Posted: April 6, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
American Academy of Allergy, Asthma, and Immunology
Information provided by:
West Penn Allegheny Health System
  Purpose

This research study involves studying the genes that may affect how ill you become during respiratory infection with respiratory syncytial virus (RSV). RSV is a virus that often causes common colds.

Cytokines are chemicals that are naturally made by your body. Cytokine levels are increased in some people when they have common colds or wheezing caused by respiratory syncytial virus (RSV). The purpose of this study is to study the genes that may control cytokine levels during infection with RSV in the elderly population.


Condition
Respiratory Syncytial Virus Infections

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Association Between Cytokine Genotype Polymorphisms and Severity of RSV-Induced Illness in the Elderly

Resource links provided by NLM:


Further study details as provided by West Penn Allegheny Health System:

Biospecimen Retention:   Samples With DNA
A buccal brushing (cells collected from the inside of the cheek) will be collected and stored for DNA analysis.

Estimated Enrollment: 300
Study Start Date: November 2007
Study Completion Date: April 2009
Primary Completion Date: April 2009 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   65 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
inpatient or outpatient subjects with respiratory illnesses potentially caused by RSV
Criteria

Inclusion Criteria:

  • Subjects > 65 years of age diagnosed with RSV-induced respiratory illness
  • Diagnosis (based upon ICD-9-CM codes) for pneumonia, upper respiratory illness, bronchitis, COPD, asthma, viral illness, or congestive heart failure (CHF)
  • Willing to sign informed consent.

Exclusion Criteria:

  • Not willing to sign informed consent.
  • Subjects less that 65 years of age
  • Subjects not diagnosed with a respiratory illness
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00609635


Locations
United States, Pennsylvania
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States, 15212
Sponsors and Collaborators
West Penn Allegheny Health System
American Academy of Allergy, Asthma, and Immunology
Investigators
Principal Investigator: Ritu Pabby, MD West Penn Allegheny Health System
  More Information

Responsible Party: Ritu Pabby, MD, Allegheny General Hosptial Dept. of Allergy, Asthma, & Immunology
ClinicalTrials.gov Identifier: NCT00609635     History of Changes
Other Study ID Numbers: Adult RSV RC# 4212
First Submitted: January 25, 2008
First Posted: February 7, 2008
Last Update Posted: April 6, 2009
Last Verified: April 2009

Keywords provided by West Penn Allegheny Health System:
Respiratory
RSV-induced respiratory illness

Additional relevant MeSH terms:
Virus Diseases
Respiratory Syncytial Virus Infections
Pneumovirus Infections
Paramyxoviridae Infections
Mononegavirales Infections
RNA Virus Infections