Association Between Cytokines and Severity of Respiratory Syncytial Virus (RSV)-Induced Illness in the Elderly

This study has been completed.
American Academy of Allergy, Asthma, and Immunology
Information provided by:
West Penn Allegheny Health System Identifier:
First received: January 25, 2008
Last updated: April 3, 2009
Last verified: April 2009

This research study involves studying the genes that may affect how ill you become during respiratory infection with respiratory syncytial virus (RSV). RSV is a virus that often causes common colds.

Cytokines are chemicals that are naturally made by your body. Cytokine levels are increased in some people when they have common colds or wheezing caused by respiratory syncytial virus (RSV). The purpose of this study is to study the genes that may control cytokine levels during infection with RSV in the elderly population.

Respiratory Syncytial Virus Infections

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Association Between Cytokine Genotype Polymorphisms and Severity of RSV-Induced Illness in the Elderly

Resource links provided by NLM:

Further study details as provided by West Penn Allegheny Health System:

Biospecimen Retention:   Samples With DNA
A buccal brushing (cells collected from the inside of the cheek) will be collected and stored for DNA analysis.

Estimated Enrollment: 300
Study Start Date: November 2007
Study Completion Date: April 2009
Primary Completion Date: April 2009 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   65 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
inpatient or outpatient subjects with respiratory illnesses potentially caused by RSV

Inclusion Criteria:

  • Subjects > 65 years of age diagnosed with RSV-induced respiratory illness
  • Diagnosis (based upon ICD-9-CM codes) for pneumonia, upper respiratory illness, bronchitis, COPD, asthma, viral illness, or congestive heart failure (CHF)
  • Willing to sign informed consent.

Exclusion Criteria:

  • Not willing to sign informed consent.
  • Subjects less that 65 years of age
  • Subjects not diagnosed with a respiratory illness
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00609635

United States, Pennsylvania
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States, 15212
Sponsors and Collaborators
West Penn Allegheny Health System
American Academy of Allergy, Asthma, and Immunology
Principal Investigator: Ritu Pabby, MD West Penn Allegheny Health System
  More Information

Responsible Party: Ritu Pabby, MD, Allegheny General Hosptial Dept. of Allergy, Asthma, & Immunology Identifier: NCT00609635     History of Changes
Other Study ID Numbers: Adult RSV RC# 4212 
Study First Received: January 25, 2008
Last Updated: April 3, 2009
Health Authority: United States: Institutional Review Board

Keywords provided by West Penn Allegheny Health System:
RSV-induced respiratory illness

Additional relevant MeSH terms:
Respiratory Syncytial Virus Infections
Virus Diseases
Mononegavirales Infections
Paramyxoviridae Infections
Pneumovirus Infections
RNA Virus Infections processed this record on May 22, 2016