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Albumin Use in Burn Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00609414
Recruitment Status : Completed
First Posted : February 7, 2008
Last Update Posted : April 18, 2011
Information provided by:
University of North Carolina, Chapel Hill

Brief Summary:
This is a study of why and how physicians use albumin during the first 72 hours after a burn injury.

Condition or disease

Detailed Description:

While albumin has been a part of burn resuscitation for many years, its use remains varied and controversial. The purpose of this study is to describe the current practices of albumin administration during the first 72 hours after a burn injury. Participating sites will collect data on patients with at least a 20% Total Body Surface Area (TBSA) burn. Information will be recorded on type and extent of burn injury, basic demographic data, co-morbidities, outcomes and, for the first 72 hours post injury, if albumin was used and why, amount of resuscitation fluids and urine output, and use of vasopressors and diuretics.

Each participating site will retrospectively review 20 charts of consecutive admissions with at least a 20% TBSA burn. In addition, each site will collect data prospectively on 20 more patients with 20% TBSA burns. Prospective data is requested in order to capture as close as possible to "real time" the reasons physicians choose to give albumin. No Protected Health Information (PHI) will be recorded.

Data will be analyzed for patterns of albumin use and reasons for albumin administration.

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Study Type : Observational
Actual Enrollment : 460 participants
Time Perspective: Prospective
Official Title: Albumin Use in Burn Patients
Study Start Date : January 2005
Actual Primary Completion Date : October 2008
Actual Study Completion Date : October 2008

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Burns

Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients who have 20% and greater Total Body Surface Area burns who received fluid resuscitation for these injuries.

Inclusion Criteria:

  • Burn Injury, with and without inhalation injury

Exclusion Criteria:

  • <20% Total Body Surface Area Burned
  • Comfort care only for the burn injury

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00609414

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United States, Arizona
Arizona Burn Center, Maricopa Medical Center
Phoenix, Arizona, United States, 85008
United States, California
Bothin Burn Center, Saint Francis Memorial Hospital
San Francisco, California, United States, 94109
United States, Florida
Shands at the University of Florida Burn Center
Gainesville, Florida, United States, 32610
United States, Georgia
Joseph M Still Research Foundation Inc and Doctors Hospital of Augusta
Augusta, Georgia, United States, 30909
United States, Kansas
Bothin Burn Center, University of Kansas Hospital
Kansas City, Kansas, United States, 66160
United States, Minnesota
Regions Hospital Burn Center
St. Paul, Minnesota, United States, 55101
United States, North Carolina
North Carolina Jaycee Burn Center, University of North Carolina Hospitals
Chapel Hill, North Carolina, United States, 27514
United States, Ohio
Paul and Carol David Foundation Burn Institute, Akron Children's Hospital
Akron, Ohio, United States, 44308
Shriners Hospitals for Children
Cincinnati, Ohio, United States, 45229
United States, Oregon
Oregon Burn Center, Legacy Health System
Portland, Oregon, United States, 97227
United States, Utah
University of Utah Hospitals Burn Center
Salt Lake City, Utah, United States, 84132
Canada, Ontario
Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Sponsors and Collaborators
University of North Carolina, Chapel Hill
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Principal Investigator: Bruce A. Cairns, MD North Carolina Jaycee Burn Center, University of North Carolina Hospitals
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Responsible Party: Bruce A. Cairns MD, Department of Surgery, University of North Carolina at Chapel Hill Identifier: NCT00609414    
Other Study ID Numbers: 04-1392
First Posted: February 7, 2008    Key Record Dates
Last Update Posted: April 18, 2011
Last Verified: April 2011
Keywords provided by University of North Carolina, Chapel Hill:
Fluid Resuscitation
Additional relevant MeSH terms:
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Wounds and Injuries