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Antioxidant Treatment of Type 2 Diabetes

This study has been completed.
Information provided by:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Identifier:
First received: January 23, 2008
Last updated: December 22, 2014
Last verified: December 2014
This study examines whether an antioxidant taken orally will improve glucose tolerance and insulin secretion in type 2 diabetic subjects.

Condition Intervention Phase
Type 2 Diabetes
Drug: Placebo
Drug: n-aceylcysteine
Early Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single Blind (Participant)
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):

Primary Outcome Measures:
  • Blood glucose [ Time Frame: 3 months ]

Secondary Outcome Measures:
  • HbA1c levels [ Time Frame: 3 months ]

Enrollment: 44
Study Start Date: July 2008
Study Completion Date: September 2013
Primary Completion Date: September 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: Placebo Drug: Placebo
one capsule BID
Active Comparator: antioxidant drug
Drug: n-aceylcysteine
450 mgm BID


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria: Subjects with a known diagnosis of type 2 diabetes -

Exclusion Criteria: None, except known intolerance to n-acetylcysteine

  Contacts and Locations
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Please refer to this study by its identifier: NCT00609102

United States, Washington
Pacific Northwest Research Institute
Seattle, Washington, United States, 98122
Sponsors and Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  More Information

Responsible Party: R. Paul Robertson, Pacific Northwest Research Institute Identifier: NCT00609102     History of Changes
Other Study ID Numbers: Antioxidant trmt type 2
NIH R01 38325-19
Study First Received: January 23, 2008
Last Updated: December 22, 2014

Keywords provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):
Type 2 diabetes

Additional relevant MeSH terms:
Diabetes Mellitus, Type 2
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Molecular Mechanisms of Pharmacological Action
Protective Agents
Physiological Effects of Drugs processed this record on May 25, 2017