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Day 3 Embryo Cryopreservation: Metabolic and Viability Analysis

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00608010
First Posted: February 6, 2008
Last Update Posted: February 6, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
V.K.V. American Hospital, Istanbul
  Purpose
Embryo preservation through freezing plays a significant role in human assisted reproduction. It provides an opportunity for patients to have more than one attempt following an ovarian stimulation cycle, thereby decreasing the exposure of patients to exogenous gonadotrophins and improving cumulative pregnancy rates. The purpose of this study is to compare effectiveness of two different freezing methods.

Condition Intervention
Fertilization in Vitro Preservation of Supernumerary Embryos Procedure: Vitrification Procedure: Slow freezing

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Day 3 Embryo Cryopreservation: Metabolic and Viability Analysis

Further study details as provided by V.K.V. American Hospital, Istanbul:

Primary Outcome Measures:
  • Blastocyst development rate [ Time Frame: 3 days after thawing ]

Enrollment: 186
Study Start Date: October 2006
Primary Completion Date: January 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Vitrification
Procedure: Vitrification
Embryos were vitrified according to a previously described technique
Active Comparator: 2
Slow freezing
Procedure: Slow freezing
Embryos were frozen with slow freezing technique

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • ICSI with own gametes
  • Couples who did not wish to cryopreserve their excess embryos for possible transfer in a future cyle
  • Donating excess embryos for research purposes

Exclusion Criteria:

  • Embryos derived from surgically retrieved spermatozoa
  • Blastocysts
  • Embryos of low quality (Grade 3 or 4 according to Hardarson)
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00608010


Locations
Turkey
American Hospital of Istanbul
Istanbul, Turkey, 34365
Sponsors and Collaborators
V.K.V. American Hospital, Istanbul
Investigators
Principal Investigator: Basak Balaban, BSc American Hospital of Istanbul
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Basak Balaban, Chief Embryologist, American Hospital of Istanbul
ClinicalTrials.gov Identifier: NCT00608010     History of Changes
Other Study ID Numbers: AH-ART-06/13
First Submitted: January 22, 2008
First Posted: February 6, 2008
Last Update Posted: February 6, 2008
Last Verified: January 2008

Keywords provided by V.K.V. American Hospital, Istanbul:
Preservation of supernumerary embryos in an IVF program