Progressive Exercise After Total Knee Arthroplasty (TKA)
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ClinicalTrials.gov Identifier: NCT00605124 |
Recruitment Status
:
Completed
First Posted
: January 30, 2008
Last Update Posted
: March 5, 2013
|
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Total knee arthroplasty (TKA) is performed more than 7.000 times a year in Finland most often for osteoarthritis (OA). While pain is predictably reduced, function does not typically ever reach that of age-matched, uninjured subjects. Quadriceps weakness has been implicated in the development and progression of knee OA and is a significant problem after TKA. Advance to return to normal daily activities is not sufficient to restore knee function or quadriceps strength after TKA.
The aim of this study is to assess the effectiveness of progressive exercise program restoring knee strength, mobility and improving the functional outcome after primary TKA.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Osteoarthritis | Other: Knee muscle exercises | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 120 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double (Investigator, Outcomes Assessor) |
Primary Purpose: | Treatment |
Official Title: | Progressive Exercise After Total Knee Arthroplasty: A Randomised Controlled Trial |
Study Start Date : | January 2008 |
Actual Primary Completion Date : | December 2010 |
Actual Study Completion Date : | December 2012 |

Arm | Intervention/treatment |
---|---|
Experimental: exercise
progressive exercise, home-based exercise program, tree exercise sessions weekly, chec-up visits every third month
|
Other: Knee muscle exercises
Home exercises three times a week, control every three months
|
Active Comparator: Conventional treatment
Normal treatment, single guidance to home exercise
|
Other: Knee muscle exercises
Home exercises three times a week, control every three months
|
- Functional tests, pain [ Time Frame: baseline , 6 weeks after operation (start of training), after 12 months training ]Timed-Up and Go-test, Visual analogue scale (VAS)
- Knee muscle strength [ Time Frame: baseline, 6 weeks after operation (start of training), after 12 months training ]isometric strength of quadriceps and hamstrings
- Health related quality of life [ Time Frame: baseline and 12 months ]SF-36
- gait analysis [ Time Frame: baseline, 6 weeks postoperatively, 12 months ]

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Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- primary unilateral TKA for knee osteoarthritis
Exclusion Criteria:
- Rheumatoid arthritis
- Fibromyalgia
- Bilateral TKA
- Heart or lung disease, which prevent training
- Unstable serious disease (cancer)
- Reduced cooperation (drug, alcohol abuse, mental illness)

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00605124
Finland | |
Ceneral Finland Health Care District | |
Jyväskylä, Finland, FIN-40620 |
Study Director: | Jari Ylinen, MD, PhD | Central Finland Health Care District | |
Study Chair: | Arja Häkkinen, PhD, Professor | Central Finland Health Care District | |
Principal Investigator: | Petri Salo, M.Sc. | Central Finland Health Care District | |
Principal Investigator: | Mirja Vuorenmaa, M.Sc. | Central Finland Health Care District | |
Study Chair: | Maija Pesola, MD | Central Finland Health Care District |
Responsible Party: | Mirja Vuorenmaa, physiotherapist, Jyväskylä Central Hospital |
ClinicalTrials.gov Identifier: | NCT00605124 History of Changes |
Other Study ID Numbers: |
KSSHP Dnro6/2007 KSSHP ( Other Identifier: KSSHP ) |
First Posted: | January 30, 2008 Key Record Dates |
Last Update Posted: | March 5, 2013 |
Last Verified: | March 2013 |
Keywords provided by Mirja Vuorenmaa, Jyväskylä Central Hospital:
osteoarthritis knee total knee arthroplasty exercise |
Additional relevant MeSH terms:
Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Rheumatic Diseases |