Progressive Exercise After Total Knee Arthroplasty (TKA)

Study Description

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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Brief Summary:

Total knee arthroplasty (TKA) is performed more than 7.000 times a year in Finland most often for osteoarthritis (OA). While pain is predictably reduced, function does not typically ever reach that of age-matched, uninjured subjects. Quadriceps weakness has been implicated in the development and progression of knee OA and is a significant problem after TKA. Advance to return to normal daily activities is not sufficient to restore knee function or quadriceps strength after TKA.

The aim of this study is to assess the effectiveness of progressive exercise program restoring knee strength, mobility and improving the functional outcome after primary TKA.

Condition or disease	Intervention/treatment	Phase
Osteoarthritis	Other: Knee muscle exercises	Not Applicable

Detailed Description:

Many studies have shown, that after TKA pain decreased significantly, but muscle strength of the operated knee did not recover and may stay under the preoperative level. To find out the effects of progressive exercise program the investigators will perform, 6 weeks after TKA, a randomized clinical trial of lower extremity strength training using two subgroups of people: traditional exercise group and progressive exercise group.

Study Design

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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Study Type :	Interventional (Clinical Trial)
Actual Enrollment :	120 participants
Allocation:	Randomized
Intervention Model:	Parallel Assignment
Masking:	Double (Investigator, Outcomes Assessor)
Primary Purpose:	Treatment
Official Title:	Progressive Exercise After Total Knee Arthroplasty: A Randomised Controlled Trial
Study Start Date :	January 2008
Actual Primary Completion Date :	December 2010
Actual Study Completion Date :	December 2012

Arms and Interventions

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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Arm	Intervention/treatment
Experimental: exercise; progressive exercise, home-based exercise program, tree exercise sessions weekly, chec-up visits every third month	Other: Knee muscle exercises; Home exercises three times a week, control every three months
Active Comparator: Conventional treatment; Normal treatment, single guidance to home exercise	Other: Knee muscle exercises; Home exercises three times a week, control every three months

Outcome Measures

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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Primary Outcome Measures :

1. Functional tests, pain [ Time Frame: baseline , 6 weeks after operation (start of training), after 12 months training ]
   Timed-Up and Go-test, Visual analogue scale (VAS)

Secondary Outcome Measures :

1. Knee muscle strength [ Time Frame: baseline, 6 weeks after operation (start of training), after 12 months training ]
   isometric strength of quadriceps and hamstrings
2. Health related quality of life [ Time Frame: baseline and 12 months ]
   SF-36
3. gait analysis [ Time Frame: baseline, 6 weeks postoperatively, 12 months ]

Eligibility Criteria

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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Ages Eligible for Study:	18 Years and older (Adult, Senior)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

• primary unilateral TKA for knee osteoarthritis

Exclusion Criteria:

• Rheumatoid arthritis
• Fibromyalgia
• Bilateral TKA
• Heart or lung disease, which prevent training
• Unstable serious disease (cancer)
• Reduced cooperation (drug, alcohol abuse, mental illness)

Contacts and Locations

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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Locations

Finland
Ceneral Finland Health Care District
Jyväskylä, Finland, FIN-40620

Sponsors and Collaborators

Jyväskylä Central Hospital

Investigators

Study Director:	Jari Ylinen, MD, PhD	Central Finland Health Care District
Study Chair:	Arja Häkkinen, PhD, Professor	Central Finland Health Care District
Principal Investigator:	Petri Salo, M.Sc.	Central Finland Health Care District
Principal Investigator:	Mirja Vuorenmaa, M.Sc.	Central Finland Health Care District
Study Chair:	Maija Pesola, MD	Central Finland Health Care District

More Information

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Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information

Responsible Party:	Mirja Vuorenmaa, physiotherapist, Jyväskylä Central Hospital
ClinicalTrials.gov Identifier:	NCT00605124 History of Changes
Other Study ID Numbers:	KSSHP Dnro6/2007; KSSHP ( Other Identifier: KSSHP )
First Posted:	January 30, 2008
Last Update Posted:	March 5, 2013
Last Verified:	March 2013

Keywords provided by Mirja Vuorenmaa, Jyväskylä Central Hospital:

osteoarthritis; knee; total knee arthroplasty; exercise

Additional relevant MeSH terms:

Osteoarthritis; Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases