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Progressive Exercise After Total Knee Arthroplasty (TKA)
This study has been completed.
Sponsor:
Jyväskylä Central Hospital
Information provided by (Responsible Party):
Mirja Vuorenmaa, Jyväskylä Central Hospital
ClinicalTrials.gov Identifier:
NCT00605124
First received: January 16, 2008
Last updated: March 4, 2013
Last verified: March 2013
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Purpose
Total knee arthroplasty (TKA) is performed more than 7.000 times a year in Finland most often for osteoarthritis (OA). While pain is predictably reduced, function does not typically ever reach that of age-matched, uninjured subjects. Quadriceps weakness has been implicated in the development and progression of knee OA and is a significant problem after TKA. Advance to return to normal daily activities is not sufficient to restore knee function or quadriceps strength after TKA.
The aim of this study is to assess the effectiveness of progressive exercise program restoring knee strength, mobility and improving the functional outcome after primary TKA.
| Condition | Intervention |
|---|---|
| Osteoarthritis | Other: Knee muscle exercises |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Investigator, Outcomes Assessor) Primary Purpose: Treatment |
| Official Title: | Progressive Exercise After Total Knee Arthroplasty: A Randomised Controlled Trial |
Resource links provided by NLM:
Further study details as provided by Mirja Vuorenmaa, Jyväskylä Central Hospital:
Primary Outcome Measures:
- Functional tests, pain [ Time Frame: baseline , 6 weeks after operation (start of training), after 12 months training ]Timed-Up and Go-test, Visual analogue scale (VAS)
Secondary Outcome Measures:
- Knee muscle strength [ Time Frame: baseline, 6 weeks after operation (start of training), after 12 months training ]isometric strength of quadriceps and hamstrings
- Health related quality of life [ Time Frame: baseline and 12 months ]SF-36
- gait analysis [ Time Frame: baseline, 6 weeks postoperatively, 12 months ]
| Enrollment: | 120 |
| Study Start Date: | January 2008 |
| Study Completion Date: | December 2012 |
| Primary Completion Date: | December 2010 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: exercise
progressive exercise, home-based exercise program, tree exercise sessions weekly, chec-up visits every third month
|
Other: Knee muscle exercises
Home exercises three times a week, control every three months
|
|
Active Comparator: Conventional treatment
Normal treatment, single guidance to home exercise
|
Other: Knee muscle exercises
Home exercises three times a week, control every three months
|
Detailed Description:
Many studies have shown, that after TKA pain decreased significantly, but muscle strength of the operated knee did not recover and may stay under the preoperative level. To find out the effects of progressive exercise program the investigators will perform, 6 weeks after TKA, a randomized clinical trial of lower extremity strength training using two subgroups of people: traditional exercise group and progressive exercise group.
Eligibility| Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- primary unilateral TKA for knee osteoarthritis
Exclusion Criteria:
- Rheumatoid arthritis
- Fibromyalgia
- Bilateral TKA
- Heart or lung disease, which prevent training
- Unstable serious disease (cancer)
- Reduced cooperation (drug, alcohol abuse, mental illness)
Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00605124
Please refer to this study by its ClinicalTrials.gov identifier: NCT00605124
Locations
| Finland | |
| Ceneral Finland Health Care District | |
| Jyväskylä, Finland, FIN-40620 | |
Sponsors and Collaborators
Jyväskylä Central Hospital
Investigators
| Study Director: | Jari Ylinen, MD, PhD | Central Finland Health Care District |
| Study Chair: | Arja Häkkinen, PhD, Professor | Central Finland Health Care District |
| Principal Investigator: | Petri Salo, M.Sc. | Central Finland Health Care District |
| Principal Investigator: | Mirja Vuorenmaa, M.Sc. | Central Finland Health Care District |
| Study Chair: | Maija Pesola, MD | Central Finland Health Care District |
More Information
| Responsible Party: | Mirja Vuorenmaa, physiotherapist, Jyväskylä Central Hospital |
| ClinicalTrials.gov Identifier: | NCT00605124 History of Changes |
| Other Study ID Numbers: |
KSSHP Dnro6/2007 KSSHP ( Other Identifier: KSSHP ) |
| Study First Received: | January 16, 2008 |
| Last Updated: | March 4, 2013 |
Keywords provided by Mirja Vuorenmaa, Jyväskylä Central Hospital:
|
osteoarthritis knee total knee arthroplasty exercise |
Additional relevant MeSH terms:
|
Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Rheumatic Diseases |
ClinicalTrials.gov processed this record on September 21, 2017