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Effect of Nutrition on Muscle Protein Synthesis

This study has been completed.
Information provided by (Responsible Party):
Milou Beelen, Maastricht University Medical Center Identifier:
First received: January 17, 2008
Last updated: April 13, 2015
Last verified: April 2015
The present proposal is designed to examine the effect of carbohydrate and protein co-ingestion on muscle protein synthesis during endurance type exercise activities. We hypothesize that muscle protein synthesis is higher when protein is co-ingested during exercise.

Condition Intervention
Dietary Supplement: carbohydrate and protein

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: The Effect of Carbohydrate and Protein Intake on Muscle Protein Synthesis During Endurance Exercise

Further study details as provided by Milou Beelen, Maastricht University Medical Center:

Primary Outcome Measures:
  • Differences in muscle protein synthesis rates between carbohydrate and carbohydrate + protein. [ Time Frame: 1 day ]

Secondary Outcome Measures:
  • Difference in whole-body protein synthesis and breakdown between carbohydrate and carbohydrate plus protein. [ Time Frame: 1 day ]

Enrollment: 12
Study Start Date: August 2008
Study Completion Date: February 2009
Primary Completion Date: February 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1 Dietary Supplement: carbohydrate and protein
The intake of carbohydrate and protein during endurance type exercise


Ages Eligible for Study:   18 Years to 28 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • recreationally endurance trained

Exclusion Criteria:

  • BMI > 25 kg/m2
  • Not physically active
  Contacts and Locations
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Please refer to this study by its identifier: NCT00604929

Sponsors and Collaborators
Maastricht University Medical Center
Principal Investigator: L van Loon, PhD Maastricht University
  More Information

Responsible Party: Milou Beelen, Dr., Maastricht University Medical Center Identifier: NCT00604929     History of Changes
Other Study ID Numbers: MEC 83017
Study First Received: January 17, 2008
Last Updated: April 13, 2015

Keywords provided by Milou Beelen, Maastricht University Medical Center:
muscle protein synthesis
whole-body protein breakdown
nutrition processed this record on May 25, 2017