Effect of Nutrition on Muscle Protein Synthesis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00604929
Recruitment Status : Completed
First Posted : January 30, 2008
Last Update Posted : April 14, 2015
Information provided by (Responsible Party):
Milou Beelen, Maastricht University Medical Center

Brief Summary:
The present proposal is designed to examine the effect of carbohydrate and protein co-ingestion on muscle protein synthesis during endurance type exercise activities. We hypothesize that muscle protein synthesis is higher when protein is co-ingested during exercise.

Condition or disease Intervention/treatment Phase
Healthy Dietary Supplement: carbohydrate and protein Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 12 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: The Effect of Carbohydrate and Protein Intake on Muscle Protein Synthesis During Endurance Exercise
Study Start Date : August 2008
Actual Primary Completion Date : February 2009
Actual Study Completion Date : February 2009

Arm Intervention/treatment
Experimental: 1 Dietary Supplement: carbohydrate and protein
The intake of carbohydrate and protein during endurance type exercise

Primary Outcome Measures :
  1. Differences in muscle protein synthesis rates between carbohydrate and carbohydrate + protein. [ Time Frame: 1 day ]

Secondary Outcome Measures :
  1. Difference in whole-body protein synthesis and breakdown between carbohydrate and carbohydrate plus protein. [ Time Frame: 1 day ]

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Ages Eligible for Study:   18 Years to 28 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • recreationally endurance trained

Exclusion Criteria:

  • BMI > 25 kg/m2
  • Not physically active

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00604929

Sponsors and Collaborators
Maastricht University Medical Center
Principal Investigator: L van Loon, PhD Maastricht University

Responsible Party: Milou Beelen, Dr., Maastricht University Medical Center Identifier: NCT00604929     History of Changes
Other Study ID Numbers: MEC 83017
First Posted: January 30, 2008    Key Record Dates
Last Update Posted: April 14, 2015
Last Verified: April 2015

Keywords provided by Milou Beelen, Maastricht University Medical Center:
muscle protein synthesis
whole-body protein breakdown