Mechanisms of Acute Asthma Exacerbations Through Molecular Analysis of Airway Secretions and Tissues (MAST-X)
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|ClinicalTrials.gov Identifier: NCT00603629|
Recruitment Status : Completed
First Posted : January 29, 2008
Last Update Posted : September 21, 2011
|Condition or disease|
Asthma is a common airway disease with persistent unmet needs in terms of treatment. Although many asthmatics enjoy good control of their disease by using regularly scheduled corticosteroid treatment, a significant minority do not achieve optimal control with steroids and suffer asthma exacerbations which can be severe and even fatal. Asthma pathophysiology is complex and involves multiple cell types and multiple signaling mechanisms. One approach to this complexity has been to study responses of isolated airway cells to experimental conditions which model asthmatic inflammation; another has been genetic manipulations of candidate mediators of asthma in inbred mice. These studies have yielded important insights about possible mechanisms of asthma in humans, but the relevance of these mechanisms to human disease has not always been proven, and it is possible that unsuspected mechanisms have not yet been revealed by these approaches.
In the current study, we propose to collect samples of airway secretions and blood from asthmatic subjects when their asthma is uncontrolled and they are being treated in the hospital or emergency room. Our goal will be to identify abnormal gene expression profiles and protein concentration abnormalities in these biological fluids. We will then study them again 6-10 weeks later when their asthma is controlled. This study design will allow us to compare airway and blood biomarkers of asthma exacerbation during acute asthma and recovery. "
|Study Type :||Observational|
|Actual Enrollment :||23 participants|
|Official Title:||A Pilot Study Determining Mechanisms of Acute Asthma Exacerbations Through Detailed Molecular Analysis of Airway Secretions and Tissues|
|Study Start Date :||January 2008|
|Actual Primary Completion Date :||September 2009|
|Actual Study Completion Date :||September 2009|
People with acute asthma in the Emergency department or inpatient settings
- gene expression in acute airway secretions and tissues [ Time Frame: 30 days ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00603629
|United States, California|
|UCSF Airway Clinical Research Center|
|San Francisco, California, United States, 94143|
|Principal Investigator:||John V Fahy, M.D., M.Sc.||University of California, San Francisco|