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Acclimatization Mechanisms During Ascent to 7500m

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00603122
First Posted: January 28, 2008
Last Update Posted: May 20, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Swiss National Science Foundation
Information provided by:
University of Zurich
  Purpose
The trial evaluates the role of ascent protocol on acute mountain sickness and cardio-respiratory physiology during an ascent to Muztagh Ata (7546m). Two groups of mountaineers ascend with different acclimatization time to the summit. The prevalence and severity of symptoms of acute mountain sickness are evaluated along with physiologic variables.

Condition Intervention
Acute Mountain Sickness Behavioral: ascent protocol

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Acclimatization Mechanisms During Ascent to 7500m. Effects of Ascent Protocol on Acute Mountain Sickness and Cardiorespiratory Physiology

Resource links provided by NLM:


Further study details as provided by University of Zurich:

Primary Outcome Measures:
  • acute mountain sickness [ Time Frame: during ascent ]

Secondary Outcome Measures:
  • mountaineering success, oxygen saturation, breathing pattern [ Time Frame: during ascent ]

Enrollment: 37
Study Start Date: March 2005
Study Completion Date: December 2005
Primary Completion Date: December 2005 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
fast ascent
Behavioral: ascent protocol
ascent protocol for the two groups has different acclimatization time
Active Comparator: 2
slow ascent
Behavioral: ascent protocol
ascent protocol for the two groups has different acclimatization time

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy, physically fit subject
  • Mountaineering experience

Exclusion Criteria:

  • Any type of cardiac or respiratory disease
  • Regular intake of any medication
  • History of high altitude pulmonary oedema
  • Severe acute mountain sickness at altitudes below 3500m or high altitude cerebral oedema.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00603122


Sponsors and Collaborators
University of Zurich
Swiss National Science Foundation
Investigators
Principal Investigator: Konrad E Bloch, MD Pulmonary Division, University Hospital of Zurich, Zurich, Switzerland
  More Information

Publications:
Responsible Party: Konrad E. Bloch, University Hospital Zurich
ClinicalTrials.gov Identifier: NCT00603122     History of Changes
Other Study ID Numbers: EK-1189
SNSF 3200B0-108300
First Submitted: January 15, 2008
First Posted: January 28, 2008
Last Update Posted: May 20, 2014
Last Verified: May 2014

Keywords provided by University of Zurich:
altitude illness
hypoxia

Additional relevant MeSH terms:
Altitude Sickness
Respiration Disorders
Respiratory Tract Diseases