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Adipokines and Ghrelin Concentrations in Different Stages of Anorexia Nervosa

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ClinicalTrials.gov Identifier: NCT00602264
Recruitment Status : Completed
First Posted : January 28, 2008
Last Update Posted : January 28, 2008
Sponsor:
Information provided by:

Study Description
Brief Summary:
The aim of this study is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of anorectic patients and to evaluate their relationships between biochemical, hormonal and anthropometric parameters.

Condition or disease
Anorexia Nervosa Adipokines

Detailed Description:

Objective: The aim of this study is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of anorectic patients and to evaluate their relationships between biochemical, hormonal and anthropometric parameters.

Design: The study group is composed of four groups. Group1: Treatment-naïve patients with a recent diagnosis of AN (n:19), Group 2: The weight recovered (10 % increase in body weight compared with baseline weight) subgroup of group 1 at the end of a mean 117.72±98.14 days of follow-up (n: 12), Group 3: Recovered patients with a previous history of AN but normal menstrual cycles and body weight at the present time (n:10), Group 4: Control group: constitutionally thin healthy young women with normal menstrual cycles (n:10). Venous blood was obtained for measurements of biochemical parameters, ApN, leptin and ghrelin and body composition was determined by bioimpedance analysis.


Study Design

Study Type : Observational
Actual Enrollment : 41 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Adipocytokine and Ghrelin Concentrations in Different Stages of Anorexia Nervosa
Study Start Date : February 2006
Study Completion Date : May 2007
Groups and Cohorts

Group/Cohort
1
Treatment-naïve patients with a recent diagnosis of anorexia nervosa
2
The weight recovered subgroup of group 1
3
Recovered patients with a previous history of anorexia nervosa but normal menstrual cycles and body weight at the present time
4
Control group


Outcome Measures

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years to 32 Years   (Child, Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Patients with anorexia nervosa and constitutionally thin healthy subjects
Criteria

Inclusion Criteria:

  • Diagnosis of anorexia nervosa for Group 1-3
  • Constitutionally thin healthy subjects for Group 4

Exclusion Criteria:

  • Medical or psychiatric diagnosis other than anorexia nervosa,
  • History of gastrointestinal disease for Group 1-3
  • History of eating disorder or gastrointestinal or psychiatric disease for control group
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00602264


Locations
Turkey
Istanbul Univetsity, Istanbul Medical Faculty, Department of Psychiatrics
Istanbul, Turkey
Sponsors and Collaborators
Istanbul University
Investigators
Study Director: Ayse Kubat Uzum, M.D Istanbul University Istanbul Medical Faculty Department of Endocrinology and Metabolism
Principal Investigator: Basak Yucel, Professor Istanbul University Istanbul Medical Faculty Department of Psychiatrics
Study Chair: Beyhan Omer, Professor Istanbul University Istanbul Medical Faculty Department of Biochemistry
Study Director: Nese Colak Ozbey, Professor Istanbul University Istanbul Medical Faculty Department of Endocrinology and Metabolism
More Information

Responsible Party: Basak Yucel, Istanbul University Istanbul Medical Faculty Department of Psychiatrics
ClinicalTrials.gov Identifier: NCT00602264     History of Changes
Other Study ID Numbers: 503/5052006
2005/1795
First Posted: January 28, 2008    Key Record Dates
Last Update Posted: January 28, 2008
Last Verified: January 2008

Keywords provided by Istanbul University:
Anorexia nervosa
Adipokines
Ghrelin
Fat mass

Additional relevant MeSH terms:
Anorexia
Anorexia Nervosa
Signs and Symptoms, Digestive
Signs and Symptoms
Feeding and Eating Disorders
Mental Disorders