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Homeostatic Sleep Regulation in Older Persons

This study has been completed.
Brigham and Women's Hospital
Information provided by:
National Institute on Aging (NIA) Identifier:
First received: October 24, 2007
Last updated: May 28, 2008
Last verified: May 2008
The purpose of this study is to test the hypothesis that sleep homeostasis, also known as sleep pressure or sleep drive, is different in healthy older and younger individuals.

Condition Intervention
Behavioral: Amount of sleep and wake

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Homeostatic Sleep Regulation in Older Persons

Further study details as provided by National Institute on Aging (NIA):

Primary Outcome Measures:
  • Total Sleep Time [ Time Frame: During inpatient study ]

Estimated Enrollment: 58
Study Start Date: September 1999
Study Completion Date: March 2004
Intervention Details:
    Behavioral: Amount of sleep and wake
    4 groups with different patterns of sleep and wake
Detailed Description:
This was an inpatient study of healthy individuals to determine whether homeostatic "sleep drive" effects on sleep change with healthy aging. Sleep, performance, and mood were studied on individuals sleeping different lengths of time and during wake periods of different durations.

Ages Eligible for Study:   18 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Ages 18-30 and 60-85 years
  • Healthy

Exclusion Criteria:

  • Any medications
  • Sleep Disorder
  Contacts and Locations
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Please refer to this study by its identifier: NCT00601445

United States, Massachusetts
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Sponsors and Collaborators
National Institute on Aging (NIA)
Brigham and Women's Hospital
Principal Investigator: Elizabeth B Klerman, MD, PhD Brigham and Women's Hospital
  More Information Identifier: NCT00601445     History of Changes
Other Study ID Numbers: AG0090
P01-AG009975 - Project 4
Study First Received: October 24, 2007
Last Updated: May 28, 2008

Keywords provided by National Institute on Aging (NIA):
Changes in sleep with aging processed this record on April 26, 2017