Melanocytic Nevi in Children Under Chemotherapy
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00600431|
Recruitment Status : Completed
First Posted : January 25, 2008
Last Update Posted : January 25, 2008
|Condition or disease|
Patients given chemotherapy because of different malignancies have an increased susceptibility to cutaneous tumours and infection and a change of number of nevi during treatment is discussed. We investigated wether total nevi count changes in children undergoing chemotherapy. Therefore 16 (8m, 8f) children suffering from leukaemia (11), lymphoma (2), adenosarcoma of the kidney (1), Ewing´s sarcoma (1) and neuroblastoma (1) aged between 2 and 17 years (median:8 years), under chemotherapy at the pediatric department of oncology, were examined at the beginning and 9-12 months after starting chemotherapy. As control group age and sex matched children of the local population were used.
Materials and Methods:
At the beginning of chemotherapy the nevi were counted on the total body. All nevi were larger in diameter than 1mm and as melanocytic lesion identifiable. Clinical and dermoscopic photographs were taken of every nevus. If the patient had more than 50 nevi, only nevi on the face, right arm, upper back and the buttocks were documented. Reassessment was repeated every 3 month.
In our patients under chemotherapy during one year the development of new nevi is similar to sex and age matched children of the general population. During this short period development of nevi seems not to be influenced by chemotherapy.
|Study Type :||Observational|
|Actual Enrollment :||32 participants|
|Observational Model:||Case Control|
|Official Title:||Melanocytic-Nevi-Counts During Chemotherapy of Children With Malignancies.|
|Study Start Date :||February 2006|
|Primary Completion Date :||December 2007|
|Study Completion Date :||December 2007|
Study group: 16 children under 18 years undergoing systemic chemotherapy
Control group: 16 age and sex matched healthy children under 18 years
- total body nevus count [ Time Frame: Every three months during a one year period ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00600431
|Department of Dermatology, Medical University of Graz|
|Graz, Austria, 8036|
|Study Chair:||Barbara Binder, MD||Department of Dermatology, Medical University of Graz, Austria|