Melanocytic Nevi in Children Under Chemotherapy
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Melanocytic-Nevi-Counts During Chemotherapy of Children With Malignancies.|
- total body nevus count [ Time Frame: Every three months during a one year period ] [ Designated as safety issue: No ]
|Study Start Date:||February 2006|
|Study Completion Date:||December 2007|
|Primary Completion Date:||December 2007 (Final data collection date for primary outcome measure)|
Study group: 16 children under 18 years undergoing systemic chemotherapy
Control group: 16 age and sex matched healthy children under 18 years
Patients given chemotherapy because of different malignancies have an increased susceptibility to cutaneous tumours and infection and a change of number of nevi during treatment is discussed. We investigated wether total nevi count changes in children undergoing chemotherapy. Therefore 16 (8m, 8f) children suffering from leukaemia (11), lymphoma (2), adenosarcoma of the kidney (1), Ewing´s sarcoma (1) and neuroblastoma (1) aged between 2 and 17 years (median:8 years), under chemotherapy at the pediatric department of oncology, were examined at the beginning and 9-12 months after starting chemotherapy. As control group age and sex matched children of the local population were used.
Materials and Methods:
At the beginning of chemotherapy the nevi were counted on the total body. All nevi were larger in diameter than 1mm and as melanocytic lesion identifiable. Clinical and dermoscopic photographs were taken of every nevus. If the patient had more than 50 nevi, only nevi on the face, right arm, upper back and the buttocks were documented. Reassessment was repeated every 3 month.
In our patients under chemotherapy during one year the development of new nevi is similar to sex and age matched children of the general population. During this short period development of nevi seems not to be influenced by chemotherapy.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00600431
|Department of Dermatology, Medical University of Graz|
|Graz, Austria, 8036|
|Study Chair:||Barbara Binder, MD||Department of Dermatology, Medical University of Graz, Austria|