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Identification of Genetic, Biochemical and Hormonal Factors Contributing to Atrial Fibrillation

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00599118
Recruitment Status : Active, not recruiting
First Posted : January 23, 2008
Last Update Posted : July 25, 2017
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:
The purpose of this study is to establish a genebank repository of blood samples and data to generate information about the hereditary (genetic) basis of atrial fibrillation.

Condition or disease
Atrial Fibrillation

Detailed Description:
Blood samples and data will be collected from subjects with atrial fibrillation and normal controls. The primary aim of future research using these samples is to identify mechanisms and pathogenesis of atrial fibrillation. Through this information, we hope to identify targets for new therapies and improve knowledge and understanding of atrial fibrillation. Identification of disease genes could improve strategies that prevent progression of atrial fibrillation to more persistent disease.

Study Design

Study Type : Observational
Estimated Enrollment : 1300 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Identification of Genetic, Biochemical and Hormonal Factors Contributing to Atrial Fibrillation
Actual Study Start Date : August 2005
Estimated Primary Completion Date : June 2020
Estimated Study Completion Date : June 2020

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Groups and Cohorts

Group/Cohort
atrial fibrillation
Atrial fibrillation
Control
Control subjects with no atrial fibrillation


Outcome Measures

Primary Outcome Measures :
  1. Genetic variants associated with atrial fibrillation [ Time Frame: Baseline ]
    Genome-wide association study of atrial fibrillation


Biospecimen Retention:   Samples With DNA
plasma, serum, buffy coat, DNA

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Subjects with atrial fibrillation
Criteria

Inclusion Criteria for Atrial Fibrillation group:

  • Male or female at least 18 years old
  • Subjects with a history of or current Atrial Fibrillation
  • Subjects able to give informed consent Exclusion Criteria for Atrial Fibrillation group: no history of atrial fibrillation

Inclusion Criteria for Controls:

  • Male or female at least 18 years old
  • Subjects with no history of Atrial Fibrillation
  • Subjects able to give informed consent Exclusion Criteria for controls: History of atrial fibrillation
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00599118


Locations
United States, Ohio
Cleveland Clinical Foundation
Cleveland, Ohio, United States, 44145
Sponsors and Collaborators
The Cleveland Clinic
Investigators
Principal Investigator: Mina K Chung, MD The Cleveland Clinic
More Information

Responsible Party: Mina Chung, Principal Investigator, The Cleveland Clinic
ClinicalTrials.gov Identifier: NCT00599118     History of Changes
Other Study ID Numbers: 8271
First Posted: January 23, 2008    Key Record Dates
Last Update Posted: July 25, 2017
Last Verified: July 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No

Keywords provided by Mina Chung, The Cleveland Clinic:
Atrial Fibrillation
Genetics

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes