Neurological Outcome With Carotid Artery Stenting (CAS)

This study has been completed.
Information provided by (Responsible Party):
Eric J. Heyer, MD, PhD, Columbia University Identifier:
First received: January 9, 2008
Last updated: February 4, 2015
Last verified: February 2015

The purpose of this study is to determine how well patients undergoing carotid artery angioplasty and/or stent-supported angioplasty for the treatment of carotid artery stenosis will perform on a battery of tests to assess brain function before and after the procedure. This study will serve as a pilot project: (a) to determine incidence of neurologic/neuropsychometric change in patients undergoing carotid artery angioplasty and/or stent-supported angioplasty, and (b) to ascertain the time it takes for these changes to resolve.

Carotid Artery Disease
Carotid Artery Stenosis
Transient Ischemic Attack

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Evaluation of Neurological Outcome in Patients Undergoing Cerebral Angiography and Revascularization Using Angioplasty and Stent-Supported Angioplasty

Resource links provided by NLM:

Further study details as provided by Columbia University:

Primary Outcome Measures:
  • Neuropsychometric Changes [ Time Frame: Baseline to 1 day post-op ] [ Designated as safety issue: No ]
    Battery of neuropsychometric tests will assess performance pre-operatively and compare the post-operative performance at 1 day.

Secondary Outcome Measures:
  • Neuropsychometric Changes [ Time Frame: Baseline to 1 month ] [ Designated as safety issue: No ]
    Battery of neuropsychometric tests will assess performance pre-operatively and compare the post-operative performance at 1 month.

Biospecimen Retention:   Samples With DNA

plasma serum DNA (obtained via buccal samples using a buccal cell collection swab)

Enrollment: 104
Study Start Date: September 2003
Study Completion Date: April 2014
Primary Completion Date: April 2014 (Final data collection date for primary outcome measure)
  Show Detailed Description


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Columbia University/NY Presbyterian Hospital


Inclusion Criteria:

  • ability to speak English

Exclusion Criteria:

  • history of permanent neurological impairment
  • Axis I psychiatric diagnosis or drug abuse
  Contacts and Locations
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Please refer to this study by its identifier: NCT00597974

United States, New York
Columbia University, Department of Anesthesiology
New York, New York, United States, 10032
Sponsors and Collaborators
Columbia University
Principal Investigator: Eric J Heyer, M.D., Ph.D. Columbia University
  More Information

Responsible Party: Eric J. Heyer, MD, PhD, Professor of Clinical Anesthesiology, Columbia University Identifier: NCT00597974     History of Changes
Other Study ID Numbers: AAAA2389
Study First Received: January 9, 2008
Last Updated: February 4, 2015
Health Authority: United States: Institutional Review Board

Keywords provided by Columbia University:
carotid artery stenosis
Neuropsychological tests
Transient ischemia

Additional relevant MeSH terms:
Carotid Artery Diseases
Carotid Stenosis
Ischemic Attack, Transient
Arterial Occlusive Diseases
Brain Diseases
Brain Ischemia
Cardiovascular Diseases
Central Nervous System Diseases
Cerebrovascular Disorders
Nervous System Diseases
Vascular Diseases processed this record on May 21, 2015