Development of a Model to Evaluate Regenerative Endodontic Techniques Using Extract Human Teeth
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ClinicalTrials.gov Identifier: NCT00595595
: January 16, 2008
Last Update Posted
: September 17, 2012
The University of Texas Health Science Center at San Antonio
Information provided by (Responsible Party):
Kenneth Hargreaves, The University of Texas Health Science Center at San Antonio
Millions of teeth are saved each year by root canal therapy. Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue in order to revitalize teeth.
Condition or disease
Dental Pulp RegenerationDental Pulp Diseases
The long term goal of this research project is to develop a method to regenerate dental pulp-like tissue as an alternative method to conventional root canal treatment. The objective of this study is to identify the methods necessary to regenerate dental pulp-like tissue in human teeth. We will collect small (~4X4mm) pieces of oral mucosa that are normally removed during surgical tooth extractions, isolate human postnatal progenitor/stem cells and, using an in vitro cell culture system, combined isolated cells with various scaffolds and test compounds to determine optimal conditions to differentiate pulp-like tissue (eg, odontoblasts, fibroblasts, endothelium, etc) grown in segments of human roots.
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Ages Eligible for Study:
16 Years to 65 Years (Child, Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients presenting for surgical removal of impacted teeth
Pre-existing indication for surgical extraction of impacted teeth
Ages less than 16 or over 65
No pre-existing indication for surgical extraction of impacted teeth